Evidence map›Paper›PMID 40458298›Full record

ArticleSurgery open science2025

Association of frailty with clinical and financial outcomes of hospitalization for non-operative trauma.

Zeyu Liu, Saad Mallick, Nam Yong Cho, Esteban Aguayo, Mahima Chillakanti, Giselle Porter, Konmal Ali, Joseph Song, Areti Tillou, Peyman Benharash

Abstract read
In one paragraph

Article in Surgery open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Water Under the Bridge: Ureteral Injury After Robotic Versus Laparoscopic Rectal Surgery.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zeyu LiuCenter for Advanced Surgical and Interventional Technology, Department of Surgery, University of California, Los Angeles, CA, United States of America.
Saad MallickCenter for Advanced Surgical and Interventional Technology, Department of Surgery, University of California, Los Angeles, CA, United States of America.
Nam Yong ChoCenter for Advanced Surgical and Interventional Technology, Department of Surgery, University of California, Los Angeles, CA, United States of America.
Esteban AguayoCenter for Advanced Surgical and Interventional Technology, Department of Surgery, University of California, Los Angeles, CA, United States of America.
Mahima ChillakantiCenter for Advanced Surgical and Interventional Technology, Department of Surgery, University of California, Los Angeles, CA, United States of America.
Giselle PorterCenter for Advanced Surgical and Interventional Technology, Department of Surgery, University of California, Los Angeles, CA, United States of America.
Konmal AliCenter for Advanced Surgical and Interventional Technology, Department of Surgery, University of California, Los Angeles, CA, United States of America.
Joseph SongCenter for Advanced Surgical and Interventional Technology, Department of Surgery, University of California, Los Angeles, CA, United States of America.
Areti TillouDivision of Trauma and Acute Care Surgery, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States of America.
Peyman BenharashCenter for Advanced Surgical and Interventional Technology, Department of Surgery, University of California, Los Angeles, CA, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: With advances in imaging and interventional techniques, traumatic injuries are increasingly managed non-operatively. However, the impact of frailty on outcomes of non-operatively managed traumatic injuries remains generally unexplored. Using a national cohort, we characterized the association of frailty with clinical and financial outcomes of non-operative trauma hospitalizations. Methods: We identified all adult (≥18 years) hospitalizations for traumatic injuries using the 2019-2021 Nationwide Readmissions Database. Only patients who did not undergo major operations were considered. Patients were then stratified into three frailty groups based on the validated Hospital Frailty Risk Score. Multivariable models were subsequently developed to assess the association of frailty with various clinical and financial outcomes. Results: Of an estimated 2,818,070 hospitalizations for non-operative trauma, 18.6 % were classified as low frailty (LF), 57.0 % as intermediate frailty (IF), and 24.4 % as high frailty (HF). Following risk adjustment, compared to LF, IF (Adjusted Odds Ratio [AOR] 2.4; 95 % Confidence Interval [CI], 2.0-3.0) and HF (AOR 3.3; 95 % CI, 2.7-4.1) were associated with greater odds of in-hospital mortality. Similarly, risks of major complications and non-home discharge elevated in a stepwise fashion. Furthermore, IF patients experienced an incremental increase in LOS of 1.3 days (95%CI, 1.2-1.4 days) and costs of $3200 (95 % CI, $3100-$3400) while HF patients had a prolonged LOS by 5.1 days (95 % CI, 4.8-5.2 days) and higher costs by $11,300 (95 % CI, $11,000-11,600). Conclusion: Our findings showed frailty status to be associated with adverse clinical outcomes and increase resource utilization among hospitalizations for non-operative trauma.

Indexed as

FrailtyNational Readmission DatabaseNon-operative managementTrauma

Identifiers

PMID40458298
PMCPMC12127545

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.