Evidence map›Paper›PMID 40458296›Full record

ArticleFrontiers in digital health2025

The development of a World Health Organization transdiagnostic chatbot intervention for distressed adolescents and young adults.

Dharani Keyan, Jennifer Hall, Stewart Jordan, Sarah Watts, Teresa Au, Katie S Dawson, Rajiah Abu Sway, Joy Crawford, Katherine Sorsdahl, Nagendra P Luitel and 15 more

Abstract read
In one paragraph

Article in Frontiers in digital health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Dharani KeyanSchool of Psychology, University of New South Wales, Sydney, NSW, Australia.
Jennifer HallDepartment of Mental Health, Brain Health and Substance Use, World Health Organization, Geneva, Switzerland.
Stewart JordanDepartment of Mental Health, Brain Health and Substance Use, World Health Organization, Geneva, Switzerland.
Sarah WattsDepartment of Mental Health, Brain Health and Substance Use, World Health Organization, Geneva, Switzerland.
Teresa AuDepartment of Mental Health, Brain Health and Substance Use, World Health Organization, Geneva, Switzerland.
Katie S DawsonSchool of Psychology, University of New South Wales, Sydney, NSW, Australia.
Rajiah Abu SwayWHO Office for West Bank and Gaza, occupied Palestinian territories.
Joy CrawfordEVE for Life, Kingston, Jamaica.
Katherine SorsdahlAlan J. Flisher Centre for Public Mental Health, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Nagendra P LuitelTranscultural Psychosocial Organization Nepal, Kathmandu, Nepal.
Anne M de GraaffDepartment of Mental Health, Brain Health and Substance Use, World Health Organization, Geneva, Switzerland.
Heba GhalayiniWar Child Holland, Amsterdam, Netherlands.
Rand HabashnehInstitute for Family Health, King Hussein Foundation, Amman, Jordan.
Hafsa El-DarderyInstitute for Family Health, King Hussein Foundation, Amman, Jordan.
Sarah FanatsehInstitute for Family Health, King Hussein Foundation, Amman, Jordan.
Aiysha MalikDepartment of Mental Health, Brain Health and Substance Use, World Health Organization, Geneva, Switzerland.
Chiara ServiliDepartment of Mental Health, Brain Health and Substance Use, World Health Organization, Geneva, Switzerland.
Muhannad FarounInstitute for Family Health, King Hussein Foundation, Amman, Jordan.
Adnan AbualhaijaInstitute for Family Health, King Hussein Foundation, Amman, Jordan.
Ibrahim Said AqelInstitute for Family Health, King Hussein Foundation, Amman, Jordan.
Syed Usman HamdaniDepartment of Primary Care and Mental Health, University of Liverpool, Liverpool, United Kingdom.
Latefa DardasCommunity Health Nursing Department, School of Nursing, University of Jordan, Amman, Jordan.
Aemal AkhtarDepartment of Mental Health, Brain Health and Substance Use, World Health Organization, Geneva, Switzerland.
Richard A BryantSchool of Psychology, University of New South Wales, Sydney, NSW, Australia.
Kenneth CarswellDepartment of Mental Health, Brain Health and Substance Use, World Health Organization, Geneva, Switzerland.

Funding

World Health Organization 001
6 · The paper itself

Abstract

Background: Common mental disorders are prevalent in young people in low- and middle-income countries (LMICs). Digitally delivered interventions have the potential to overcome many structural and psychosocial barriers to mental health care. Chatbots have been proposed as one potentially acceptable and feasible method that may increase engagement. Yet, there is currently limited evidence for their efficacy in reducing psychological distress. This paper summarises the development of a World Health Organization digital psychological intervention for young people experiencing impairing psychological distress, developed in line with Human Centred Design (HCD) principles. Objective: This study refined and adapted a chatbot intervention initially developed for adolescents aged 15-18 years that was completed in consultation with end-users in this age group ( Methods: The current study followed a limited user-centred design process involving focus groups and key informant interviews with stakeholders including young adults aged 18-21 years ( Results: There was a clear preference for a chatbot based intervention that included interactions with fictional characters with relatable problems. The chatbot content followed a transdiagnostic model that addressed common problems including low mood, stress and anger with reference to vocational, familial and interpersonal stressors that the target population commonly faced. It followed a non-AI decision tree format with multiple sessions and was designed to be adaptable for use in different countries with different populations and software systems. Prototype versions of the chatbot were well-received by adolescents (15-18-year-old) and young adults (18-21-year-old). Conclusions: This is the first report of the development of a chatbot intervention for adolescents and young adults in LMICs that was designed using a HCD framework. Systematic end-user engagement through all phases of the research aimed to make this intervention acceptable and useable for adolescents and young adults in a wide variety of settings. The chatbot is currently being tested in randomised controlled trials in Jordan and Lithuania.

Indexed as

chatbotlow-and-middle income countriespsychological distressuser-centred designyouth

Identifiers

PMID40458296
PMCPMC12128417

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.