ArticleFrontiers in bioengineering and biotechnology2025
How do compression and flexion-compression injuries destabilize the spine? A novel
Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Coupled motions of the spine under standardizedFrontiers in bioengineering and biotechnology · 2025Pooled it
- Inducing thoracolumbar burst fractures in human cadaveric specimens using a combined axial-flexion loading: a fracture simulation.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Effect of total ligamentum flavum removal on increased motion and reduced stiffness: anFrontiers in medicine · 2026Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Introduction: Unstable traumatic spinal injuries require surgical stabilization. However, biomechanical instability of specific spinal injuries has been little investigated, although restoring stability represents a primary goal of surgical treatment. This study aimed (1) to develop an Methods: Mechanical fracture simulation was performed on twelve fresh-frozen human spine specimens (T9-11; 4 f/8 m; 40-60 years) using a material testing machine. Pure compression trauma (n = 6) was simulated by applying displacement-controlled axial compression at 300 mm/s until 20% compression of the T10 vertebral body height. Flexion-compression trauma (n = 6) was achieved by additional flexural loading of 10 Nm. Pre- and post-traumatic pure moment testing with 5 Nm was performed in flexion/extension, lateral bending, and axial rotation using optical motion tracking to determine range of motion (ROM), neutral zone (NZ), coupled rotations, and coupled translations. Translations under shear loading of 100 N and axial deformation under 400 N compression were analyzed. Results: All specimens exhibited AOSpine A1 injuries occurring at a median fracture load of 5.0 kN (2.4-9.2 kN). Pure compression generated isolated medial endplate fractures (n = 5), while flexion-compression primarily provoked combined endplate and ventral compression injuries (n = 3). Significant (p < 0.05) increases were detected for all parameters except for coupled rotations and posterior (compression) and left shear translation (flexion-compression). Highest instability increases were determined for axial deformability (compression: +136% / flexion-compression: +200%) and NZ (flexion/extension: +177% / 188%; lateral bending: +174% / +126%). Mild to moderate disc degeneration and age did not correlate with fracture loads (p > 0.05). In compression trauma, cortical bone mineral density (BMD) of T10 had no effect on fracture loads (p > 0.05), whereas in flexion-compression trauma, a significant (p < 0.05) linear correlation was found (Spearman's r Discussion: Relevant instability parameters of minor compression and flexion-compression injuries include axial deformability, NZ, ROM, and coupled translations. Cortical BMD of the target vertebra solely affects fracture generation in flexion-compression trauma. Consequently, risk factors for fracture development may vary between trauma mechanisms.
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