ArticleFrontiers in plant science2025
Fruit-specific overexpression of lipoyl synthase increases both bound and unbound lipoic acid and alters the metabolome of tomato fruits.
Article in Frontiers in plant science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Lipoic acid (LA) is a key, yet overlooked player in primary metabolism, due to its role as a cofactor for various multi enzymatic complexes such as the E2 subunits of pyruvate dehydrogenase (PDH) and alpha-ketoglutarate dehydrogenase (kGDH). In recent years, this molecule has seen renewed interest given its strong antioxidant properties and its applications as a dietary supplement. The mechanisms behind the synthesis of LA in vivo have been elucidated, identifying lipoyl synthase (LIP1) as the key enzyme required for this process. Methods: Therefore, in this work, we used the fruit-specific polygalacturonase (PG) promoter to guide Results: The resulting plants presented higher transcript levels of Discussion: In addition, as the overexpression of
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