Evidence map›Paper›PMID 40458201›Full record

ArticleFrontiers in oral health2025

Utilizing a naturopathic mouthwash with selective antimicrobial effects against multispecies oral biofilms for prevention of dysbiosis.

Danyal A Siddiqui, Yi-Wen C Tsai, Juliana Giron Bastidas, Marzieh S Jazaeri, Georgios A Kotsakis

Abstract read
In one paragraph

Article in Frontiers in oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Danyal A SiddiquiDepartment of Oral Biology, Rutgers School of Dental Medicine, Newark, NJ, United States.
Yi-Wen C TsaiTranslational Periodontal Research Lab, Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.
Juliana Giron BastidasDepartment of Oral Biology, Rutgers School of Dental Medicine, Newark, NJ, United States.
Marzieh S JazaeriDepartment of Oral Biology, Rutgers School of Dental Medicine, Newark, NJ, United States.
Georgios A KotsakisDepartment of Oral Biology, Rutgers School of Dental Medicine, Newark, NJ, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Oral rinses intended for the prevention and treatment of periodontal diseases have traditionally focused on bactericidal effects. This study evaluates the efficacy of a naturopathic mouthwash containing plant attenuations and propolis against common gram- pathogenic and gram+ commensal oral species in comparison to conventional antiseptic oral rinses. Methods: Results: SL significantly inhibited the growth of disease-associated Discussion: The SL homeopathic rinse demonstrated selective action on oral bacteria, preferentially reducing pathogen bacterial load while preserving commensal species with high cytocompatibility. Future validation in human studies is needed to assess its selective antimicrobial activity to maintain a eubiotic oral microbiome and explore broader applications in oral health.

Indexed as

antimicrobial(s)chlorhexidinegingivitisoral biofilmsoral rinsesperiodontitis

Identifiers

PMID40458201
PMCPMC12127372

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.