ArticleiScience2025
Biophysical characterization of the recording of unmyelinated and myelinated fiber activity with peripheral interfaces.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- The optimization of neuroprosthetic interfaces relying on biophysical and surrogate digital twins.npj biomedical innovations · 2026Review
- Potential Histological Benefits of Gabapentin in Experimental Facial Nerve Crush Injury in Rats: Increased Myelinated Axons and S100-Positive Schwann Cells.Iranian journal of otorhinolaryngology · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unmyelinated fibers account for a remarkable fraction of the peripheral nervous system and their activity is linked to many autonomic and somatic functions. While electrical recording of such activity from human-sized peripheral nerves holds significant potential for neuroengineering applications, it has been shown only in acute settings via microneurography. This leaves unclear whether current implantable electrodes could achieve the same outcome. To address this matter, we simulated recordings from the human vagus nerve through a transverse intrafascicular multichannel electrode (TIME), a microneurographic (μNG) needle, and a commercial cuff electrode. Recording signals were studied fiber-wise across relevant electrode insertions, revealing that the possibility of recording unmyelinated activity is shared by the TIME but unlikely by the cuff. These results suggest that no physical limitations of implantable electrodes underlie the missing evidence of recordings from unmyelinated fibers, and draw attention to experimental design choices that may have concealed this capability thus far.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.