ArticleJDS communications2025
Beyond immunoglobulin G: Dissecting the role of colostrum in programming early immune function in calves.
Article in JDS communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Impact of interspecies colostrum and milk replacement on circulating sncRNA dynamics of neonatal goat kids.RNA biology · 2026Article
- Review
- Graded selenium supplementation restructures yak colostrum composition and metabolomic organization under high-altitude conditions.Food chemistry: X · 2026Article
- Impact of Dam Lactation Number on Colostrum Quality, Calf Growth, and Economic Performance in Holstein Cows.Veterinary sciences · 2026Article
- MicroRNAs from colostrum and mature cow milk: High-throughput sequencing and functional enrichment.Food chemistry. Molecular sciences · 2026Article
- Saliva Immunoglobulin Concentrations Are Associated with Colostrum Intake and with Serum Concentrations in Newborn Calves.Animals : an open access journal from MDPI · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adequate colostrum intake is essential for neonatal calf health and development, not only reducing disease incidence but also promoting accelerated growth, earlier reproductive maturity, improved first-lactation milk yields, and lower culling rates. Although these advantages might be partly attributed to antibody-mediated disease prevention, emerging evidence highlights the critical role of colostrum's bioactive components in programming postnatal development. Colostrum's nutrient and bioactive composition is uniquely tailored to meet the developmental needs of newborn calves. Compared with mature milk, colostrum contains higher concentrations of proteins, fats, vitamins, and minerals, along with an array of growth factors and bioactive molecules that exert a foundational influence on the adaptation to extrauterine life. A deeper understanding of how these colostrum bioactive components collectively influence calf health is important to improve colostrum management and pave the way for refined nutritional and care strategies to support calves during this critical developmental period. In this review, we explore the multifaceted role of bovine colostrum beyond transfer of passive immunity, focusing on its influence in modulating early microbial encounters and guiding neonatal immune development.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.