ArticleSurgical case reports2025
Histiocytic Sarcoma Diagnosed on Repeat Biopsy of Multifocal Extranodal Tumors.
Article in Surgical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionHistiocytic sarcoma (HS) is a rare malignant disease with a poor prognosis and unknown pathogenesis. In addition, this disease is difficult to diagnose due to the wide variety of diseases to be differentiated from it. CASE PRESENTATION: A 37-year-old woman with right-sided chest pain was referred to our hospital. Computed tomography (CT) revealed a 30-mm mass with osteolytic changes in the right eighth rib. Further examination revealed a rib mass, right renal mass, anterior mediastinal nodule, bilateral pulmonary nodules, and suprasellar nodule. A needle biopsy of the rib mass revealed granuloma with histiocytes. A subsequent needle biopsy of the right renal mass revealed similar findings without evidence of malignancy. The imaging findings suggested malignant disease; therefore, wedge resection of the upper lobe of the right lung and biopsy of the mediastinal mass were performed under general anesthesia. HS was diagnosed based on the immunostaining results.
conclusionsFor the treatment of HS, early intervention is said to contribute to a prolonged prognosis. In order to provide appropriate therapy, HS should be included in the differential diagnosis for multifocal extranodal tumors.
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