Evidence map›Paper›PMID 40458087›Full record

ReviewCardiovascular therapeutics2025

Characteristics of Cardiac Ketone Body Metabolism Throughout the Life Cycle.

Lei Li, Xiaojian Song, Xiurui Ma, Yanwu Xu

Abstract readReview
In one paragraph

Review in Cardiovascular therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lei LiDepartment of Cardiology, Shan Xi Cardiovascular Hospital, Taiyuan, China.ORCID https://orcid.org/0009-0008-4004-6595
Xiaojian SongDepartment of Cardiology, Shan Xi Cardiovascular Hospital, Taiyuan, China.
Xiurui MaDepartment of Cardiology, Shan Xi Cardiovascular Hospital, Taiyuan, China.ORCID https://orcid.org/0000-0003-3681-2804
Yanwu XuDepartment of Biochemistry, School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID https://orcid.org/0000-0002-9253-7790

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ketone bodies can serve as energy substrates for the heart and perform important molecular signal transduction functions. In recent years, the therapeutic potential of ketone bodies has become a research hotspot in the field of cardiovascular diseases. Many previous reviews have focused on ketone bodies from the perspective of cardiovascular diseases, especially heart failure. Nonetheless, the metabolism of cardiac ketone bodies under physiological conditions also warrants attention, as the consumption of a ketogenic diet or direct supplementation of ketone bodies from exogenous sources has become widely popular among healthy individuals for weight loss. Furthermore, recent clinical studies have shown that under physiological conditions, the level of ketone bodies is positively correlated with the incidence of cardiovascular diseases and mortality. On the basis of the differences in cardiac ketone body metabolism under healthy and disease conditions, in this review, we describe in detail the characteristics of cardiac ketone body metabolism and the significance of elevated circulating ketone body levels throughout the life cycle on physiological states.

Indexed as

Cardiovascular DiseasesEnergy MetabolismKetone BodiesMyocardiumAnimalsDiet, KetogenicHumansKetone Bodiesheartketone bodymetabolismphysiology

Identifiers

PMID40458087
PMCPMC12127125

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.