ArticleThe Journal of clinical endocrinology and metabolism2025
Hair Cortisone Levels and the Metabolic Syndrome: Stronger Links in Younger Compared to Older Adults.
Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Hair cortisol as a marker of glucocorticoid replacement adequacy in adrenal insufficiency.Frontiers in endocrinology · 2026Article
- Hair Cortisone Levels and the Metabolic Syndrome: Stronger Links in Younger Compared to Older Adults.The Journal of clinical endocrinology and metabolism · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundThe striking link between Cushing syndrome, the metabolic syndrome (MetS), and cardiovascular disease suggests that long-term exposure to high glucocorticoid levels catalyzes cardiometabolic deterioration. However, the relation of subtle variations in long-term glucocorticoid levels with MetS remains poorly understood. Specifically, little is known about potential moderating roles of age, sex, and mental health status in this association.
designWe investigated the association of long-term glucocorticoid levels with MetS using data of 1405 participants (73.4% women) of the Netherlands Study of Depression and Anxiety. Predictors included hair cortisol and cortisone levels. Outcomes were MetS presence, number of MetS components, and individual component (ie, diastolic blood pressure, waist circumference, and fasting glucose, high-density lipoprotein cholesterol, and triglycerides). We investigated potential interactions with age, sex, and mental health status.
resultsHair glucocorticoid levels were positively associated with MetS presence (OR = 1.27; 95% CI = 1.11-1.44, and OR = 1.32; 95% CI = 1.14-1.52 for hair cortisol and cortisone, respectively), number of MetS components, waist circumference, and triglyceride levels. Hair cortisol, but not cortisone, was in trend associated with diastolic blood pressure and high-density lipoprotein cholesterol levels. No associations were seen with blood glucose. Of note, the relationship of hair cortisone with MetS was stronger among younger compared to older individuals (OR = 1.95; 95% CI = 1.50-2.54 vs OR = 1.14; 95% CI = .96-1.35 in younger vs older participants).
conclusionLong-term biological stress, measured through hair glucocorticoid levels, is associated with MetS presence, especially among younger individuals. Prospective studies need to evaluate the extent to which hair cortisol and cortisone add to standard risk factors when predicting future cardiometabolic diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.