Evidence map›Paper›PMID 40458034›Full record

ArticlePlant biotechnology journal2025

The receptor-like protein RXEG1 confers broad-spectrum resistance in soybean and cotton by recognizing microbial glycoside hydrolase 12 proteins.

Mengzhu Zeng, Ping Qiu, Haibing Ouyang, Yujing Sun, Zhiyuan Chen, Yuanyuan Cheng, Mingmei Zhang, Yu Ye, Lei Wang, Zuling Zheng and 7 more

Abstract read
In one paragraph

Article in Plant biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Mengzhu Zeng *State Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Ping Qiu *National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.
Haibing OuyangState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Yujing SunState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Zhiyuan ChenState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Yuanyuan ChengState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Mingmei ZhangState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Yu YeState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Lei WangState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Zuling ZhengState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Hao WangState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Tianyao LiuState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Wei ZhaoInstitute of Plant Protection and Agro-Products Safety, Anhui Academy of Agricultural Sciences, Hefei, China.
Kaixuan DuanState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.ORCID https://orcid.org/0000-0001-8729-3106
Yan WangState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.ORCID https://orcid.org/0000-0001-7465-5518
Longfu ZhuNational Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.ORCID https://orcid.org/0000-0002-4947-8609
Yuanchao WangState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.ORCID https://orcid.org/0000-0001-5803-5343

Funding

National Key Research and Development Program of China 2022YFF1001500National Natural Science Foundation of China 32172423National Natural Science Foundation of China 32322070Zhongshan Biological Breeding Laboratory ZSBBL-KY2023-03
6 · The paper itself

Abstract

Plants diseases cause substantial crop yield loss and threaten food security. Enhancing plant genetic resistance is a major strategy to mitigate the impact of plant diseases on agricultural production. The leucine-rich repeat receptor-like protein RXEG1 recognizes the glycoside hydrolase 12 (GH12) protein XEG1 secreted by Phytophthora sojae to mount immune responses in Nicotiana benthamiana. Here, we found that RXEG1 broadly recognizes multiple GH12 proteins of oomycete and fungal pathogens. Structural modelling and mutagenesis analyses of critical interacting residues revealed that RXEG1 binds to the enzyme-activated pocket of different GH12 proteins through an amino-terminal and a carboxy-terminal loopout region (RXEG1

Indexed as

Disease ResistanceGlycine maxGlycoside HydrolasesGossypiumPlant DiseasesPlant ProteinsPhytophthoraPlants, Genetically ModifiedGlycoside HydrolasesPlant Proteinsglycoside hydrolase 12 proteinsimmune recognitionplant immune receptorsoybean diseaseVerticillium wilt

Identifiers

PMID40458034
PMCPMC12310859

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.