ArticleCurrent drug discovery technologies2026
Breaking Boundaries in Cancer Therapy: Harnessing Chromothripsisinduced Mutations for Targeted Bcl-2 Protein Destabilization.
Article in Current drug discovery technologies, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Chromothripsis, a phenomenon of massive genomic rearrangements, introduces extensive mutations in critical genes, affecting cell survival and apoptosis. Among these genes, the BCL-2 (Bcell lymphoma 2) gene, which plays a crucial antiapoptotic role in cancer cells, is often subjected to significant alterations. Here, we present a computational pipeline to model and analyze the structural and functional impacts of chromothripsis-induced Single-Nucleotide Polymorphisms (SNPs) within the BCL-2 gene. This pipeline integrates mutation simulation, homology modeling, and protein interaction analysis to evaluate the stability and apoptotic potential of BCL-2 mutations. These results indicate that chromothripsis-induced mutations can destabilize the BCL-2 protein, thereby disrupting its binding affinity with apoptotic regulators, such as Bax. These findings support the potential of ergodic anticancer therapy to exploit such mutations, facilitating the apoptosis of cancer cells. Our computational model offers a novel
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