Evidence map›Paper›PMID 40457622›Full record

ArticleMagnetic resonance in medicine2025

Accelerating 3D radial MPnRAGE using a self-supervised deep factor model.

Yan Chen, Steve R Kecskemeti, James H Holmes, Curtis A Corum, Nima Yaghoobi, Vincent A Magnotta, Mathews Jacob

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yan ChenElectrical and Computer Engineering, University of Virginia, Charlottesville, Virginia, USA.ORCID https://orcid.org/0009-0003-6886-1886
Steve R KecskemetiWaisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0003-3589-430X
James H HolmesDepartment of Radiology, University of Iowa, Iowa City, Iowa, USA.ORCID https://orcid.org/0000-0002-0936-3700
Curtis A CorumDepartment of Radiology, University of Iowa, Iowa City, Iowa, USA.ORCID https://orcid.org/0000-0002-4994-6206
Nima YaghoobiElectrical and Computer Engineering, University of Virginia, Charlottesville, Virginia, USA.ORCID https://orcid.org/0009-0001-4657-7716
Vincent A MagnottaDepartment of Radiology, University of Iowa, Iowa City, Iowa, USA.ORCID https://orcid.org/0000-0001-8639-5354
Mathews JacobElectrical and Computer Engineering, University of Virginia, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0001-6196-3933

Funding

Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Brittany Gail Travers · 2021 to 2026
$8.5M
University of Iowa Hawkeye Intellectual and Developmental Disabilities Research Center (Hawk-IDDRC)P50HD103556 · NICHD · UNIVERSITY OF IOWA · PI EDWIN TED G. ABEL, Lane Strathearn · 2021 to 2026
$8.5M
Next Generation Pediatric Neuroimaging (NGPN) DevelopmentR44MH122028 · NIMH · CHAMPAIGN IMAGING, LLC · PI Curtis Andrew Corum · 2024 to 2026
$4.3M
Novel Computational Framework for Free-Breathing & Ungated Dynamic MRIR01EB019961 · NIBIB · UNIVERSITY OF VIRGINIA · PI Mathews Jacob · 2016 to 2026
$4.0M
Model Based Deep Learning Framework for Ultra-High Resolution Multi-Contrast MRIR01AG067078 · NIA · UNIVERSITY OF VIRGINIA · PI JACOB, MATHEWS · 2021 to 2025
$3.4M
Motion Robust Relaxometry for Infant NeuroimagingR01HD108868 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI ALEXANDER, ANDREW L, GILLICK, BERNADETTE THERESE · 2022 to 2025
$2.5M
High Resolution MRSI for Alzheimer's Disease and Related DementiasR01AG087159 · NIA · UNIVERSITY OF IOWA · PI Mathews Jacob, Yan Li · 2024 to 2026
$2.3M
University of Iowa - Research 3T MRI Connectome UpgradeS10OD025025 · OD · UNIVERSITY OF IOWA · PI MAGNOTTA, VINCENT A · 2018 to 2018
$1.9M
Fast Multi-dimensional Diffusion MRI with Sparse Sampling and Model-basedDeep Learning ReconstructionR01EB031169 · NIBIB · UNIVERSITY OF VIRGINIA · PI MANI, MERRY · 2021 to 2024
$1.7M
Next Generation Pediatric Neuroimaging (NGPN) FeasibilityR43MH122028 · NIMH · CHAMPAIGN IMAGING, LLC · PI CORUM, CURTIS ANDREW · 2020 to 2022
$1.5M
GE HealthcareNIA NIH HHS R01 AG067078NIA NIH HHS R01 AG087159NIBIB NIH HHS R01 EB019961NIBIB NIH HHS R01 EB031169NICHD NIH HHS P50 HD103556NICHD NIH HHS P50 HD105353NICHD NIH HHS R01 HD108868NIH HHS P50HD103556NIH HHS R01AG067078NIH HHS R01AG087159NIH HHS R01EB019961NIH HHS R01EB031169NIH HHS R01HD108868NIH HHS R43MH122028NIH HHS S10 OD025025NIH HHS S10OD025025NIMH NIH HHS R43 MH122028NIMH NIH HHS R44 MH122028
6 · The paper itself

Abstract

purposeTo develop a self-supervised and memory-efficient deep learning image reconstruction method for 4D non-Cartesian MRI with high resolution and a large parametric dimension.

methodsThe deep factor model (DFM) represents a parametric series of 3D multicontrast images using a neural network conditioned by the inversion time using efficient zero-filled reconstructions as input estimates. The model parameters are learned in a single-shot learning (SSL) fashion from the k-space data of each acquisition. A compatible transfer learning (TL) approach using previously acquired data is also developed to reduce reconstruction time. The DFM is compared to subspace methods with different regularization strategies in a series of phantom and in vivo experiments using the MPnRAGE acquisition for multicontrast

resultsDFM-SSL improved the image quality and reduced bias and variance in quantitative

conclusionThe proposed DFM offers a superior representation of the multicontrast images compared to subspace models, especially in the highly accelerated MPnRAGE setting. The self-supervised training is ideal for methods with both high resolution and a large parametric dimension, where training neural networks can become computationally demanding without a dedicated high-end GPU array.

Indexed as

Deep LearningImage Processing, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingAlgorithmsBrainHumansImage Interpretation, Computer-AssistedNeural Networks, ComputerPhantoms, ImagingMPnRAGEmulti‐contrast MRIquantitative MRIsingle‐shot reconstruction

Identifiers

PMID40457622
PMCPMC12202740

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.