Evidence map›Paper›PMID 40457616›Full record

ArticleThe journal of obstetrics and gynaecology research2025

Multicenter cohort study of the effect of Crinone® progesterone vaginal gel alone to prepare the endometrium for frozen-thawed blastocyst transfer in a hormone replacement cycle.

Akiko Takashima, Yukihiro Shibui, Toshio Hamatani, Akihiko Suenaga, Yoshimitsu Kuwabara, Fuminori Kimura, Koji Nakagawa, Yusuke Fukuda, Shoji Tokunaga, Yukiko Katagiri

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of obstetrics and gynaecology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Akiko TakashimaDepartment of Obstetrics and Gynecology, Toho University Medical Center Sakura Hospital, Chiba, Japan.ORCID https://orcid.org/0000-0002-7156-1054
Yukihiro ShibuiCinema Art Clinic, Tokyo, Japan.
Toshio HamataniDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Akihiko SuenagaNishitan ART clinic Shinagawa, Tokyo, Japan.
Yoshimitsu KuwabaraDepartment of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan.ORCID https://orcid.org/0000-0002-1622-4063
Fuminori KimuraDepartment of Obstetrics and Gynecology, Shiga University of Medical Science, Shiga, Japan.ORCID https://orcid.org/0000-0002-9840-4227
Koji NakagawaDivision of Reproductive Medicine, Sugiyama Clinic, Tokyo, Japan.
Yusuke FukudaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Toho University, Tokyo, Japan.
Shoji TokunagaThe Medical Information Center, Kyushu University Hospital, Fukuoka, Japan.
Yukiko KatagiriDepartment of Obstetrics and Gynecology, Faculty of Medicine, Toho University, Tokyo, Japan.

Funding

Merck Biopharma Co., Ltd
6 · The paper itself

Abstract

aimProgesterone has to be administered to prepare the endometrium for frozen-thawed blastocyst transfer (FBT) in a hormone replacement cycle (HRC). The objective of this study was to investigate the efficacy and safety of using Crinone® progesterone gel alone in HRC-FBT.

methodsIn this multicenter prospective study, HRC-FBT was performed with blastocysts with a Gardner's classification of 3BB or better, and application of 90 mg/day of vaginal gel (Crinone, Merck BioPharma, Tokyo) was started when the endometrial thickness reached 8 mm or more. The primary endpoint was the clinical pregnancy rate (CPR). Safety endpoints included genital bleeding and other adverse events. Recruitment started in May 2018.

resultsA total of 181 patients were enrolled, and 156 were included in the efficacy analysis. The overall CPR was 41.7% (65/156). In patients younger than 38 years (n = 113), the CPR was 48.7% (55/113), and in those aged 38 years or older (n = 43), it was 23.3% (10/43). The overall CPR was comparable to that observed in the Japan Society of Obstetrics and Gynecology ART2020 National Survey, which reported a pregnancy rate of 36.3% in frozen embryo transfer cycles. Adverse events such as light genital bleeding occurred before and after pregnancy in some patients, but at a low frequency (<10%).

conclusionsUse of Crinone progesterone vaginal gel alone is adequate in HRC-FBT and is not associated with any safety issues.

Indexed as

Embryo TransferEndometriumHormone Replacement TherapyProgesteroneVaginal Creams, Foams, and JelliesAdministration, IntravaginalAdultCryopreservationFemaleHumansPregnancyPregnancy RateProspective StudiesCrinoneProgesteroneVaginal Creams, Foams, and Jelliesfrozen–thawed embryo transferhormone replacementluteal phase supportpregnancy rateprogesterone

Identifiers

PMID40457616
PMCPMC12130669

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.