Evidence map›Paper›PMID 40457610›Full record

Observational studyCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions2025

Early Stroke Volume Variation After Transcatheter or Surgical Aortic Valve Replacement Predicts Clinical Outcomes in Low-Flow Aortic Stenosis.

Giorgio Fiore, Federico Biondi, Paola Cunsolo, Michele Morosato, Marco Gamardella, Giacomo Ingallina, Stefano Stella, Francesco Ancona, Annamaria Tavernese, Davide Margonato and 5 more

Abstract readObservational Study
In one paragraph

Observational study in Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Giorgio FioreUnit of Cardiovascular Imaging, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID 0000-0002-5726-8396
Federico BiondiUnit of Cardiovascular Imaging, IRCCS Ospedale San Raffaele, Milan, Italy.
Paola CunsoloUnit of Cardiovascular Imaging, IRCCS Ospedale San Raffaele, Milan, Italy.
Michele MorosatoUnit of Cardiovascular Imaging, IRCCS Ospedale San Raffaele, Milan, Italy.
Marco GamardellaUnit of Cardiovascular Imaging, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID 0009-0009-6004-7103
Giacomo IngallinaUnit of Cardiovascular Imaging, IRCCS Ospedale San Raffaele, Milan, Italy.
Stefano StellaUnit of Cardiovascular Imaging, IRCCS Ospedale San Raffaele, Milan, Italy.
Francesco AnconaUnit of Cardiovascular Imaging, IRCCS Ospedale San Raffaele, Milan, Italy.
Annamaria TaverneseUnit of Cardiovascular Imaging, IRCCS Ospedale San Raffaele, Milan, Italy.
Davide MargonatoUnit of Cardiovascular Imaging, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID 0000-0002-5817-6901
Margherita FabrisUnit of Cardiovascular Imaging, IRCCS Ospedale San Raffaele, Milan, Italy.
Alessandro CastiglioniDepartment of Cardiac Surgery, IRCCS Ospedale San Raffaele, Milan, Italy.
Matteo MontorfanoVita-Salute San Raffaele University, Milan, Italy.
Francesco MaisanoDepartment of Cardiac Surgery, IRCCS Ospedale San Raffaele, Milan, Italy.
Eustachio AgricolaUnit of Cardiovascular Imaging, IRCCS Ospedale San Raffaele, Milan, Italy.

Funding

The authors received no specific funding for this work.
6 · The paper itself

Abstract

backgroundLittle is known about stroke volume index (SVi) change and its prognostic implication in patients with low-flow aortic stenosis (AS) undergoing aortic valve replacement (AVR) and conflicting results are present in literature. The aim of this study was to evaluate the postoperative change in SVi and its impact on outcomes in patients with low-flow severe AS undergoing AVR.

methodsRetrospective observational study of a high-volume tertiary care center including consecutive patients with low-flow (SVi ≤ 35 mL/m

resultsOne-hundred-fifty-one patients (mean age 80 ± 8 years, 53.6% female) were included. After AVR, SVi improved by > 15% in 51 (33.8%) and normalized in 51 (33.8%) patients. At a median follow-up of 17 (7-32) months, 62 (52.6%) patients reached the primary composite endpoint. SVi improvement, but not SVi normalization, was associated with better survival free from the primary endpoint (log rank p = 0.02 and 0.056, respectively). Multivariate analysis confirmed that both SVi improvement and its absolute change per mL/m

conclusionsIn patients with low-flow AS undergoing AVR, early post-procedural SVi increase has beneficial prognostic significance. These findings highlight the importance of post-AVR hemodynamic assessment and may help refine risk stratification in this vulnerable population.

Indexed as

Aortic ValveAortic Valve StenosisHeart Valve Prosthesis ImplantationStroke VolumeTranscatheter Aortic Valve ReplacementVentricular Function, LeftAgedAged, 80 and overFemaleHeart FailureHumansMaleRecovery of FunctionRetrospective StudiesRisk AssessmentRisk Factorsaortic stenosisaortic valve replacementlow flowLVOT VTIstroke volume index

Identifiers

PMID40457610
PMCPMC12336788

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.