Evidence map›Paper›PMID 40457526›Full record

ArticleCNS neuroscience & therapeutics2025

Intra-Arterial Deoxyribonuclease Therapy Improves Stroke Outcomes in Aged Mice.

Junxiang Yin, Michael Wu, Jennifer White, Ellie StClair, J Mocco, Michael F Waters

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Junxiang YinDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-4361-3347
Michael WuDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jennifer WhiteBarrow-ASU Center for Preclinical Imaging, Barrow Neurological Institute, Phoenix, Arizona, USA.
Ellie StClairColorado School of Mines, Golden, Colorado, USA.
J MoccoDepartment of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Michael F WatersDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Funding

Barrow Neurological Foundation #3033227Icahn School of Medicine at Mount Sinai #02482323
6 · The paper itself

Abstract

backgroundFutile recanalization affects more than half of acute ischemic stroke (AIS) patients. Neutrophil extracellular traps (NETs) are a major factor of microvascular hypoperfusion after stroke. Deoxyribonuclease I (DNase) targeting NETs exhibited a neuroprotective effect in young mice with AIS. This study explored a novel direct intra-arterial administration of DNase therapy and its effect in aged mice with AIS.

methodAIS was induced in aged C57BL/6 mice followed by reperfusion and immediate, intra-arterial DNase administration via the internal carotid artery. Cerebral blood flow (CBF), neurological function, cerebral infarct volume, and NET markers were examined.

resultsDirect intra-arterial DNase therapy significantly increased CBF, reduced neurological deficit scores, increased the latency to fall in the wire hang test, reduced cerebral infarct volume, and decreased neutrophil and NET count in both the parenchyma and micro vessels in aged mice with AIS compared with age-matched vehicle controls.

conclusionOur data is the first to demonstrate that successful, direct intra-arterial DNase therapy provides more efficient cerebral reperfusion and better outcomes after recanalization during the treatment of large vessel occlusion in aged mice. This study provides evidence for the potential clinical application of catheter-delivered intra-arterial DNase therapy post-recanalization.

Indexed as

AgingDeoxyribonuclease IDeoxyribonucleasesIschemic StrokeStrokeAnimalsCerebrovascular CirculationExtracellular TrapsInjections, Intra-ArterialMaleMiceMice, Inbred C57BLTreatment OutcomeDeoxyribonuclease IDeoxyribonucleasesacute ischemic strokedeoxyribonucleasefutile recanalizationintra‐arterial therapyneutrophilneutrophil extracellular traps

Identifiers

PMID40457526
PMCPMC12129710

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.