ArticleEuropean journal of medical research2025
Sleep quality and its determinants in patients with thyroid eye disease: a cross-sectional study.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Impacts of Thyroid Eye Disease (TED), Beyond the Signs and Symptoms: Results from the ElevaTED Patient Survey.Ophthalmology and therapy · 2026Article
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7 authors.
Funding
Abstract
backgroundSleep disorders may impair the nervous and immune systems. In thyroid eye disease (TED), an autoimmune condition, sleep quality and its potential determinants remain unclear. The study aimed to assess the sleep quality of patients with TED and identify its determinants.
methodA questionnaire was used to collect the clinical information of patients with TED and controls in a hospital. The data included the participants' demographic characteristics, the Pittsburgh Sleep Quality Index (PSQI) score, and Self-rating Anxiety Scale (SAS) score. The sleep quality was compared between the TED and control groups. Furthermore, binary logistic regression analysis was used to detect the determinants of sleep quality, while linear regression was used to evaluate the relationships between PSQI and potential determinants.
resultsOverall, 52 patients with TED and 75 healthy individuals were enrolled in this study. In the TED group, 59.6% of patients experienced sleep disorders, compared to only 33.3% in the control group. Additionally, the PSQI scores of patients with TED tended to be higher than those of controls (p = 0.002). Binary logistic regression revealed that a high SAS score was an independent risk factor for poorer sleep quality in patients with TED. Furthermore, patients with TED with higher GO-QoL visual function scores tended to have lower sleep scores.
conclusionsPatients with TED often experience sleep disorders, which are related to anxiety and visual impairment. Sleep disorders should be considered in managing patients with TED in clinical practice.
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