Evidence map›Paper›PMID 40457463›Full record

SynthesisJournal of medical case reports2025

Fluorodeoxyglucose positron emission tomography-computed tomography missed tibial metastasis in head and neck cancer: a case report and review of literature.

Hamidreza Movahedi, Lena Nazemi, Saina Ghadiany, Alireza Movahedi, Farzad Dehghani Mahmoudabadi, Mohammadhossein Aghazadeh, Seyed Esmaeil Mousavi, Shaghayegh Khodabakhshian

Abstract readCase ReportsSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hamidreza MovahediDepartment of General Surgery, School of Medicine, Ayatollah Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Lena NazemiSchool of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Saina GhadianyFaculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 1985717443, Iran.
Alireza MovahediDepartment of General Surgery, School of Medicine, Ayatollah Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Farzad Dehghani MahmoudabadiDepartment of General Surgery, School of Medicine, Ayatollah Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammadhossein AghazadehDepartment of General Surgery, School of Medicine, Ayatollah Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Seyed Esmaeil MousaviSchool of Medicine, Iran University of Medical Sciences, Tehran, Iran. mousavi.esmaeil1998@gmail.com.ORCID http://orcid.org/0009-0005-6826-447X
Shaghayegh KhodabakhshianDepartment of General Surgery, School of Medicine, Ayatollah Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHead and neck squamous cell carcinoma is the seventh most common type of cancer in the world. Metastases occur in up to 40% of cases, and bones are the second most frequent site. Metastases in extremities are uncommon, with very few publications covering distal lower-limb bone metastasis. CASE PRESENTATION: Here we report the case of a 47-year-old Persian man with head and neck squamous cell carcinoma managed by induction chemotherapy, surgery, and adjuvant chemoradiotherapy. During the adjuvant treatment, the patient experienced right tibial pain, with additional workup revealing a distal lower-limb bone metastasis that had remained undetected during the standard workup for head and neck squamous cell carcinoma. DISCUSSION: In current guidelines, recommended fluorodeoxyglucose positron emission tomography-computed tomography in head and neck squamous cell carcinoma does not extend below the popliteal fossae. The undetected metastasis led to overtreatment of this patient. Systematic review of literature showed only six cases of distal lower-limb metastasis from head and neck cancer, which are eligible for discussion.

conclusionAlthough rare, physicians should keep in mind that as recommended fluorodeoxyglucose positron emission tomography-computed tomography does not extend below the popliteal fossae, metastases may be missed, potentially leading to overtreatment.

Indexed as

Bone NeoplasmsCarcinoma, Squamous CellHead and Neck NeoplasmsPositron Emission Tomography Computed TomographySquamous Cell Carcinoma of Head and NeckTibiaFluorodeoxyglucose F18HumansMaleMiddle AgedRadiopharmaceuticalsFluorodeoxyglucose F18RadiopharmaceuticalsBone metastasisFDG PET–CTHead and neck cancerLower-limb metastasisOral cancerTibial metastasis

Identifiers

PMID40457463
PMCPMC12128323

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.