Evidence map›Paper›PMID 40457448›Full record

ArticleItalian journal of pediatrics2025

Continuous renal replacement therapy in extremely low birth weight infants: a series of 5 cases.

Lin Cheng, Ying Li, Li He, Zhuo-Ying Li, Xin-Lin Yin, Shang-Ping Zhao, Sheng-Feng Wang, Wen-Juan Zhou, Min Kong, Shen-Tang Li and 11 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Italian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Lin ChengNeonatal Intensive Care Unit, Department of Pediatrics, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Ying LiNeonatal Intensive Care Unit, Department of Pediatrics, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Li HeNeonatal Intensive Care Unit, Department of Pediatrics, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Zhuo-Ying LiPediatric Intensive Care Unit, Department of Pediatrics, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Xin-Lin YinDepartment of Anesthesiology, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Shang-Ping ZhaoDepartment of Intensive Care Unit, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Sheng-Feng WangDepartment of Pharmacy, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Wen-Juan ZhouNeonatal Intensive Care Unit, Department of Pediatrics, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Min KongNeonatal Intensive Care Unit, Department of Pediatrics, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Shen-Tang LiPediatric Intensive Care Unit, Department of Pediatrics, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Jing TianNeonatal Intensive Care Unit, Department of Pediatrics, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Na JiangNeonatal Intensive Care Unit, Department of Pediatrics, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yi XiongNeonatal Intensive Care Unit, Department of Pediatrics, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Lin-Xia DengNeonatal Intensive Care Unit, Department of Pediatrics, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Ya-Qing ShenNeonatal Intensive Care Unit, Department of Pediatrics, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Zhou LiNeonatal Intensive Care Unit, Department of Pediatrics, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Fang ChenNeonatal Intensive Care Unit, Department of Pediatrics, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Cong-Hua KuangNeonatal Intensive Care Unit, Department of Pediatrics, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Si-Min PengNeonatal Intensive Care Unit, Department of Pediatrics, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yin-Jun LiNeonatal Intensive Care Unit, Department of Pediatrics, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Tao BoNeonatal Intensive Care Unit, Department of Pediatrics, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China. 603039@csu.edu.cn.ORCID http://orcid.org/0009-0006-6785-0511

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundContinuous renal replacement therapy (CRRT) plays a pivotal role in delivering renal support to critical patients with acute kidney injury (AKI). However, administering CRRT to extremely low birth weight (ELBW) infants, defined as those with a birth weight under 1000 g, presents distinct challenges. We summarized our experiences of the ELBW infants who were treated with CRRT at a tertiary medical center in China, and evaluated its feasibility and safety in this group of patients.

methodsELBW infants were performed CRRT at the neonatal intensive care unit (NICU), the Third Xiangya Hospital of Central South University, a tertiary medical center in China, between 2021 and 2023.

resultsA total of 5 ELBW infants with a minimum birth weight of 450 g were involved in this study. At the commencement of CRRT, four patients still weighed less than 1000 g, with the lowest being 700 g. We placed a 5.0Fr double-lumen catheter in the internal jugular vein or femoral vein under ultrasound guidance. The extracorporeal circuit was primed with compatible blood. CRRTs were successfully initiated in all patients. Four patients completed CRRT as planned, and the maximum cumulative CRRT time was 65 h. Only two patients were still alive at 28-day, but eventually dropped out of treatment for severe neurological sequelae.

conclusionsThis is the first research of ELBW infants' CRRT in China. Our findings indicate that CRRT may be feasible in ELBW infants, but improving the survival rate and long-term prognosis remains a challenge in those newborns undergoing such procedure.

Indexed as

Acute Kidney InjuryContinuous Renal Replacement TherapyInfant, Extremely Low Birth WeightChinaFeasibility StudiesFemaleHumansInfantInfant, NewbornIntensive Care Units, NeonatalMaleTreatment OutcomeAcute kidney injuryContinuous renal replacement therapyExtremely low birth weight infantsPreterm neonates

Identifiers

PMID40457448
PMCPMC12131604

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.