ReviewJournal of translational medicine2025
Mitochondrial dynamics reveal potential to facilitate axonal regeneration after spinal cord injury.
Review in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- A Unified Framework for Spinal Cord Injury Repair: Metabolic-Nutritional Microenvironment Remodeling, Immune Modulation, and Neural Regeneration.Molecular neurobiology · 2026Review
- Chemogenetic Activation of Neurons Promotes Axonal Regeneration and Ameliorates Neurological Deficits in Mice with Intracerebral Hemorrhage by Modulating Mitochondrial Function.Neuromolecular medicine · 2026Article
- The Fidelity Paradox in Spinal Cord Injury: Reframing Biomechanical Mimicry and Neurobiological Relevance for Clinical Translation.CNS neuroscience & therapeutics · 2026Review
- Adipose tissue-derived stromal cells enhance glycolytic metabolism in injured nerve cells via the FOXK1-HK2 axis for spinal cord injury repair.Journal of translational medicine · 2026Article
- Effects of GLP-1 Receptor Agonist Exenatide on Mitochondrial Dysfunction After Spinal Cord Injury.Neurotrauma reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundSpinal cord injury (SCI) arises from traumatic damage to the spinal cord, resulting in varying degrees of sensory, motor, and autonomic dysfunction. Mitochondria, as the primary energy-producing organelles within cells, have garnered increasing attention for their critical role in promoting axonal regeneration following SCI. AIM OF REVIEW: This review aims to systematically examine the alterations in mitochondrial dynamics post-SCI and to elucidate their influence on axonal regeneration. Furthermore, the review evaluates the current challenges associated with SCI treatment and proposes potential therapeutic strategies for future research. KEY SCIENTIFIC CONCEPTS OF REVIEW: The review comprehensively addresses mitochondrial dynamics, with a focus on key processes such as biogenesis, fusion and fission, mitophagy, trafficking, and anchoring. It delves into the molecular mechanisms by which signaling pathways within neurons and glial cells regulate these mitochondrial processes to facilitate axonal regeneration. Additionally, the review identifies existing challenges in SCI treatment and advocates for targeted interventions in mitochondrial dynamics as a promising therapeutic avenue, offering significant potential for advancing future research and treatment of SCI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.