ArticleItalian journal of pediatrics2025
Dynamic changes of serum matrix metalloproteinases and tissue inhibitors in Kawasaki disease: implications for coronary artery lesions persistence.
Article in Italian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Advance in the Kawasaki disease related coronary artery aneurysms: knowledge mapping, trends, and research frontiers.Journal of cardiothoracic surgery · 2026Review
- NLRP3 Inflammasome Activation Mediates Coronary Artery Lesions in Kawasaki Disease by Inducing Endothelial Cells Pyroptosis and Glycocalyx Injury.Immunity, inflammation and disease · 2026Article
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Authors and funding
7 authors.
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Abstract
backgroundThe mechanism of coronary artery lesions (CALs) persistence in Kawasaki disease (KD) remains unclear. The study aimed to investigate the serum dynamic changes of matrix metalloproteinases (MPPs) and tissue inhibitors (TIMPs) in children with CALs caused by KD, and explore their correlation with short-term CAL outcomes.
methodsThis is a nested case-control study. A total of 114 KD children with CALs completed the 3-month follow-up in discovery set and validation set. Children with CALs persisted after 3 months were enrolled as the CALs persistence group. The CALs regression group consisted of children with CALs regressed who were matched with each CALs persisted case by gender and age at a ratio of 2:1. In the discovery set, serum MMPs and TIMPs were measured using a Quantibody
resultsThere were 8 (13.3%) KD children with CALs that persisted for 3 months in the discovery set, including 4 boys and 4 girls, with a median age of 3.00 years. In the febrile phase, there were no differences in MMPs and TIMPs between CALs persistence group and CALs regression group (P>0.05). After treatment, MMP-8 and MMP-9 decreased in both groups, while TIMP-1 was lower in CALs persistence group (P<0.05). Further validation study showed the same changes.
conclusionsMMPs and TIMPs have dynamic changes in children with CALs caused by KD. A low level of TIMP-1 after treatment may be related to CALs persistence, offering novel insights into the underlying mechanism.
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