Evidence map›Paper›PMID 40457355›Full record

ArticleJournal of neuroinflammation2025

Brd4 expression in CD4 T cells and in microglia promotes neuroinflammation in experimental autoimmune encephalomyelitis.

Anup Dey, Matthew Butcher, Anne Gegonne, Ryoji Yagi, Keita Saeki, Eunju Lee, Dinah S Singer, Jinfang Zhu, Keiko Ozato

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Aberrant CD4bioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anup DeyDivision of Developmental Biology, NICHD, NIH, Bethesda, MD, USA. deya@dir6.nichd.nih.gov.
Matthew ButcherLaboratory of Immune System Biology NIAID, NIH, Bethesda, MD, USA.
Anne GegonneExperimental Immunology Branch, CCR, NCI, NIH, Bethesda, MD, USA.
Ryoji YagiLaboratory of Immune System Biology NIAID, NIH, Bethesda, MD, USA.
Keita SaekiDivision of Developmental Biology, NICHD, NIH, Bethesda, MD, USA.
Eunju LeeDivision of Developmental Biology, NICHD, NIH, Bethesda, MD, USA.
Dinah S SingerExperimental Immunology Branch, CCR, NCI, NIH, Bethesda, MD, USA.
Jinfang ZhuLaboratory of Immune System Biology NIAID, NIH, Bethesda, MD, USA.
Keiko OzatoDivision of Developmental Biology, NICHD, NIH, Bethesda, MD, USA. keiko.ozato@nih.gov.

Funding

Gene Regulation In The Immune SystemZIAHD001310 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI OZATO, KEIKO · 2009 to 2025
$15.0M
GENE REGULATION IN THE IMMUNE SYSTEMZ01HD001310 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI OZATO, KEIKO · 1988 to 2008
$1.8M
Intramural NIH HHS Z01 HD001310Intramural NIH HHS ZIA HD001310Intramural Research program, NICHD, NIH. ZIA HD001310-35
6 · The paper itself

Abstract

Microglia are resident innate immune cells in the central nervous system (CNS) that provides anti-microbial protection but also promote neuroinflammation. BRD4 is a chromatin reader that binds to acetylated histones and directs transcription of numerous genes. However, it is unknown whether and how BRD4 regulates microglia function. We addressed the role of microglia and BRD4 in a neuroinflammatory disease, experimental autoimmune encephalomyelitis (EAE), a mouse model for multiple sclerosis. It was reported earlier that in EAE, upon initial T cell activation in the peripheral lymphoid organs, CD4

Indexed as

CD4-Positive T-LymphocytesCell Cycle ProteinsEncephalomyelitis, Autoimmune, ExperimentalMicrogliaNeuroinflammatory DiseasesTranscription FactorsAnimalsBromodomain Containing ProteinsFemaleMiceMice, Inbred C57BLMice, KnockoutNuclear ProteinsBrd4 protein, mouseBromodomain Containing ProteinsCell Cycle ProteinsNuclear ProteinsTranscription FactorsBRD4Brd4cKOCNSEAEMicrogliaMOGNeuroinflammationRNA-seqTh17 T cells

Identifiers

PMID40457355
PMCPMC12131476

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.