ArticleBMC public health2025
Trends in alcohol-associated liver disease mortality rates in American Indians and Alaskan Natives.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Temporal trends and demographic disparities in mortality with co-mention of chronic liver disease and pneumonia in the United States, 1999-2024.BMC gastroenterology · 2026Article
- Trends and Demographics of Hepatorenal Syndrome-Related Mortality in the U.S., 1999-2024: A CDC WONDER Analysis.Diseases (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionA leading cause of death among non-Hispanic American Indians or Alaskan Natives (AI/ANs), apart from cardiovascular disease and unintentional injuries, is chronic liver disease (CLD). This study analyzed recent trends in AI/AN ALD mortality, given their increased incidence of alcoholic liver disease (ALD) and high burden of CLD.
methodsThis cross-sectional study used data from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER). Geographic, age and sex-based temporal mortality trends of ALD deaths were analyzed among the AI/AN population in the US from 1999 to 2020. Joinpoint regression analyses determined trends in ALD crude and age-adjusted mortality rates, identifying the annual percent change (APC) in each subgroup.
resultsIn 1999-2020, the overall age-adjusted mortality rate (AAMR) among AI/ANs increased significantly from 27.2/100,000 to 88.4/100,000. Although men had a higher mortality rate overall, women had a higher increase in APC (2003-2008 APC was 17.7 [95% Cl: 9.9-26.0] and 2018-2020 APC was 25.3 [95% Cl: 11.4-40.9]) compared to men (1999-2020 APC was 5.8 [95% Cl 4.8-6.8]). All age groups studied witnessed an increase in AAMR. However, the age group 45-64 had the highest mortality overall in the preceding 2 decades. Non-metropolitan geographic regions had the highest mortality rate (2018-2020 APC of 25.5 [95% Cl: 5.0-50.0]) compared to medium/small or large metro areas. Western and Midwestern US Census regions had the highest mortality rates.
conclusionsMale sex, age 44-65, and rural dwelling was associated with a greater ALD AAMR in AI/AN populations. Social changes due to the Covid-19 pandemic may have led to increased ALD mortality. Discerning the underlying causality of these associations and examining the impact of the social determinants of health, may represent important opportunities to enhance care for AI/ANs as a vulnerable minority population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.