ArticleBMC musculoskeletal disorders2025
Tracing neurodevelopment and growth pattern in six-year-old children with idiopathic clubfoot: a national cohort study.
Article in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
STUDY
designPopulation-based retrospective cohort study.
objectivesThe developmental impact of idiopathic clubfoot on children remains underexplored. This study investigates neurodevelopment and physical growth in children with idiopathic clubfoot up to age six.
methodsThis population-based retrospective cohort study was conducted in South Korea (2009-2019) using linked data from National Health Insurance Service. The cohort included children diagnosed with idiopathic clubfoot and 1:10 exact match of healthy control children. Neurodevelopmental assessments were conducted using the validated Korean Developmental Screening Test, which covers six domains: gross motor skills, fine motor skills, cognition, language, social skills, and self-regulation, for children aged 42-71 months. Secondary outcomes measured were height and body mass index (BMI) Z-score during the same period.
resultsThe cohort comprised 484 children with idiopathic clubfoot and 4,840 matched healthy control children. Children with clubfoot had a higher rate of premature birth (7.44% vs. 3.66%, p < 0.0001) and lower birth weight (3.08 ± 0.59 kg vs. 3.20 ± 0.46 kg, p < 0.0001) compared to the healthy control children. In-depth evaluation of all six neurodevelopmental domains showed significant differences in children with clubfoot (overall aOR, 3.671; 95% CI, 2.463-5.471). Children with clubfoot showed a significant height delay (Z score, -1.63 below), but no BMI difference was noted.
conclusionsChildren with idiopathic clubfoot demonstrated increased risk of neurodevelopmental delays and reduced height compared to their peers. These findings underscore the importance of early recognition and ongoing monitoring by parents and pediatricians.
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