Trial reportBMC oral health2025
Supplementary zinc and vitamin D in management of symptomatic oral lichen planus: a three-arm randomized clinical trial.
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04765267 (Evaluation of Micronutrients With Topical Corticosteroid Versus Topical Corticosteroid in Management of Symptomatic Oral Lichen Planus), which is not on this map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Micronutrients With Topical Corticosteroid Versus Topical Corticosteroid in Management of Symptomatic Oral Lichen Planus: Three-arm Randomized Clinical Trial
Who cites it
5 citing papers in PubMed.
- Non-Pharmacological Treatments for Oral Carcinogenesis: From Oral Lichen Planus to Oral Squamous Cell Carcinoma.Cancers · 2026Review
- Clinicopathological characteristics and follow-up outcomes of patients with oral potentially malignant disorders: A 7-year observational cohort study.Scientific reports · 2026Observational
- Relationship Between Anemia and Oral Lichen Planus: New Therapeutic Perspectives Based on Anemia Management-A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Decoding orofacial pain: a translational review of mechanisms and novel therapies.The journal of headache and pain · 2025Review
- Role of micronutrition in patients with oral cancer and nutritional intervention strategies.Frontiers in nutrition · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOral lichen planus (OLP) is a chronic inflammatory disease affecting the oral mucosa, with immune mediated pathogenesis. Both zinc and vitamin D are essential micronutrients implicated in OLP pathogenesis, with zinc influencing epithelial growth, wound healing, and oxidative stress mitigation, while vitamin D modulates immune cell function, cytokine activity, and keratinocyte behavior. The current trial was conducted to assess the effect of topical corticosteroid supplemented with zinc or vitamin D compared to topical corticosteroid in management of symptomatic oral lichen planus.
methodsForty-two patients diagnosed with symptomatic oral lichen planus (atrophic, erosive, or bullous types) were included in the study, based on clinical examination and histopathological confirmation in accordance with the modified World Health Organization (WHO) criteria (2003). Participants were divided randomly into three parallel groups. Group I received topical corticosteroid; Group II received topical corticosteroid with systemic zinc; Group III received topical corticosteroid with systemic vitamin D. The outcome measures included pain intensity using Visual Analogue Scale and clinical improvement using Thongprasom et al. scoring system. Treatment lasted for 8 weeks; patients were clinically evaluated at baseline and on weekly basis.
resultsIntergroup comparisons revealed that by Week 3, pain scores were significantly lower in Groups II and III compared to Group I. Intragroup analysis showed significant reductions in pain scores over time for all groups, with Group II showing the most pronounced decrease from baseline to Week 7. Thongprasom scores decreased significantly in all groups, with Group II showing the most significant reduction by Week 8.
conclusionsSystemic zinc supplementation combined with topical corticosteroid can be used as an adjunct therapy for OLP management. Topical corticosteroid supplemented with vitamin D has comparable effect to topical corticosteroid alone on pain and clinical improvement in symptomatic OLP. CLINICAL
trial registrationNCT04765267 (full protocol can be accessed). Date of Initial Clinical Trial Registration: 4 February 2021.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.