Evidence map›Paper›PMID 40457253›Full record

ArticleJournal of nanobiotechnology2025

A minimalist self-assembly nanosystem for cancer immunotherapy via multiple immune activation.

Weizhe Xu, Shiyuan Wang, Jiayi Zhang, Fang Wang, Zhaogang Sun, Bei Liu, Jun Ye, Hongqian Chu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Weizhe Xu *Translational Medicine Center, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Research Institute, Capital Medical University, Beijing, 101149, China.
Shiyuan Wang *State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
Jiayi ZhangTranslational Medicine Center, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China.
Fang WangTranslational Medicine Center, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China.
Zhaogang SunTranslational Medicine Center, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Research Institute, Capital Medical University, Beijing, 101149, China.
Bei LiuCollege of Science, Minzu University of China, Beijing, 100081, China. liubeinano@163.com.
Jun YeState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China. yelinghao@imm.ac.cn.
Hongqian ChuTranslational Medicine Center, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Research Institute, Capital Medical University, Beijing, 101149, China. chuhongqian@bjxkyy.cn.

Funding

Capital Medical University Outstanding Young Talents Project B2407National Key Research and Development Program of China 2023YFC2706100National Natural Science Foundation of China 82304393Tongzhou District Health Development Research Reserve Project Foundation KJ2024CX024
6 · The paper itself

Abstract

In recent years, anti-tumor immunity has emerged as a central focus in cancer research, with the rapid advancement of immunotherapy heralding a new era in cancer treatment. Despite the significant potential of immunotherapy, the use of single-agent approaches or limited combination therapies has not consistently yielded optimal therapeutic outcomes. The strategic and controlled integration of diverse immune activation techniques within a single nanoparticle, utilizing a straightforward and universal methodology, continues to present a substantial challenge. Self-assembly, as a simple synthesis method, offers the possibility of combining multiple therapeutic approaches through straightforward means. In this study, we developed a novel approach to construct a biocompatible nanosystem, named Cu-ICG-CpG-FA (CICF), which was synthesized through one-pot coordination-driven self-assembly of Cu

Indexed as

ImmunotherapyNanoparticlesNeoplasmsAnimalsCell Line, TumorCopperFemaleFolic AcidHumansIndocyanine GreenMiceOligodeoxyribonucleotidesPhotochemotherapyCopperCPG-oligonucleotideFolic AcidIndocyanine GreenOligodeoxyribonucleotidesChemodynamic therapyImmunotherapyPhotodynamic therapyPhotothermal therapySelf-assembly

Identifiers

PMID40457253
PMCPMC12131631

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.