Evidence map›Paper›PMID 40457215›Full record

ArticleBMC cardiovascular disorders2025

Coronary angiogenesis in small-cell lung carcinoma: embolization of a left circumflex artery feeding vessel to a lung tumor and concurrent coronary revascularization.

Muath A Baniowda, Malak Ramzy Hroub, Abdalhakim Shubietah, Mahmoud Doudein, Qutaiba Qafisheh, Omar Hamadi, Hasan Munshi, Ahmed Hamed

Abstract readCase Reports
In one paragraph

Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Muath A BaniowdaDepartment of Internal Medicine, University of Missouri-Kansas City, Kansas City, USA.
Malak Ramzy HroubFaculty of Medicine, Al-Quds University, Jerusalem, Palestine.
Abdalhakim ShubietahDepartment of Internal Medicine, Advocate Illinois Masonic Medical Center, Chicago, IL, USA.
Mahmoud DoudeinCardiology Department, Specialized Arab Hospital, Nablus, Palestine. dodenmahmoud@yahoo.com.
Qutaiba QafishehDepartment of Internal Medicine, University of Toledo, Toledo, OH, USA.
Omar HamadiFaculty of Medicine, Al-Quds University, Jerusalem, Palestine.
Hasan MunshiDepartment of Internal Medicine, St. Joseph's University Medical Center, Paterson, NJ, USA.
Ahmed HamedInterventional Cardiology Consultant and Head of the Cardiology Department, Al-Istishari Arab Hospital, Ramallah, Palestine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSmall-cell lung carcinoma (SCLC) can exhibit exuberant angiogenesis, but direct arterial feeders arising from coronary vessels are exceedingly rare. We report a case of a LCX coronary artery supplying a lung tumor, successfully managed with coil embolization. CASE PRESENTATION: A 64-year-old man with SCLC presented with a 7 × 8 cm left hilar mass, dyspnea, pleuritic chest pain, hoarseness, and 18 kg weight loss. Two months after starting chemotherapy, he developed an inferior STEMI. Angiography showed proximal LAD ectasia with an atherosclerotic stenosis, total RCA occlusion (culprit lesion), and ectatic LCX branches perfusing the tumor. The RCA STEMI was addressed first with emergent revascularization, followed by PCI of the LAD and embolization of the tumor-feeding artery. Fractional flow reserve was not assessed, and aspiration thrombectomy was not performed. The LCX feeder was embolized using detachable, fiber-coated platinum microcoils delivered through a microcatheter. Post-embolization angiography confirmed complete occlusion without complications. Two-month follow-up CT demonstrated tumor regression to 4.5 × 4 cm and marked relief of dyspnea, chest pain, and hoarseness. No tissue was available to exclude microscopic tumor emboli, but angiographic features favored plaque-rupture thrombosis rather than malignant embolization.

conclusionThis case underscores the importance of recognizing coronary feeding arteries in lung cancer and illustrates a multidisciplinary strategy-sequential PCI and targeted embolization-that achieved both oncologic (tumor devascularization and shrinkage) and cardiac (symptom control, revascularization) goals.

Indexed as

Coronary CirculationCoronary VesselsEmbolization, TherapeuticLung NeoplasmsNeovascularization, PathologicPercutaneous Coronary InterventionSmall Cell Lung CarcinomaST Elevation Myocardial InfarctionAngiogenesisCoronary AngiographyHumansMaleMiddle AgedTreatment OutcomeAngiogenesisSmall-cell lung carcinomaTumor-feeding branch from coronary arteryTumor shrinkage

Identifiers

PMID40457215
PMCPMC12128266

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.