Evidence map›Paper›PMID 40457116›Full record

Trial reportJournal of general internal medicine2025

Understanding the characteristics and comorbidities of primary care patients with risky opioid use: Baseline data from the multi-site "Subthreshold Opioid Use Disorder Prevention" (STOP) Trial.

Yasna Rostam-Abadi, Jane M Liebschutz, Geetha Subramaniam, Rebecca Stone, Noa Appleton, Shayna Mazel, Karen Alexander, Seuli Bose Brill, Ashley Case, Lillian Gelberg and 10 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of general internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04218201 (Subthreshold Opioid Use Disorder Prevention), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04218201 nacompletednot on this map

Subthreshold Opioid Use Disorder Prevention (STOP) Trial

TypeinterventionalSponsorNYU Langone HealthRan2020 to 2024Enrolled321ConditionsOpioid-use DisorderArmsPCP brief advice, Video doctor, Telephone health coaching, Nurse Care Manager (NCM) intervention
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yasna Rostam-AbadiDepartment of Population Health, NYU Grossman School of Medicine, 180 Madison Ave, New York, NY, 10016, USA.
Jane M LiebschutzCenter for Research on Health Care, Division of General Internal Medicine, University of Pittsburgh, UPMC, Pittsburgh, PA, 15213, USA.
Geetha SubramaniamNational Institute on Drug Abuse, North Bethesda, MD, 20852, USA.
Rebecca StoneDepartment of Population Health, NYU Grossman School of Medicine, 180 Madison Ave, New York, NY, 10016, USA.
Noa AppletonDepartment of Population Health, NYU Grossman School of Medicine, 180 Madison Ave, New York, NY, 10016, USA.
Shayna MazelDepartment of Population Health, NYU Grossman School of Medicine, 180 Madison Ave, New York, NY, 10016, USA.
Karen AlexanderFriends Research Institute, Baltimore, MD, 21201, USA.
Seuli Bose BrillDepartment of Medicine, Ohio State University College of Medicine, Columbus, OH, 43210, USA.
Ashley CaseThe Emmes Company, LLC, Rockville, MD, 20850, USA.
Lillian GelbergDavid Geffen School of Medicine at UCLA, and Fielding School of Public Health, Los Angeles, CA, 90095, USA.
Adam J GordonDepartment of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, 84132, USA.
Hyunouk HongDepartment of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH, 03755, USA.
Michael A InczeDivision of General Internal Medicine, University of Utah, Salt Lake City, UT, 84132, USA.
Sarah S KawasakiDepartment of Psychiatry and Internal Medicine, Penn State College of Medicine, Hershey, PA, 17033, USA.
Tobie KimThe Emmes Company, LLC, Rockville, MD, 20850, USA.
Margaret KlineThe Emmes Company, LLC, Rockville, MD, 20850, USA.
Travis I LovejoyOregon Health and Science University, Portland, OR, 97239, USA.
Jennifer McCormackThe Emmes Company, LLC, Rockville, MD, 20850, USA.
Song ZhangThe Emmes Company, LLC, Rockville, MD, 20850, USA.
Jennifer McNeelyDepartment of Population Health, NYU Grossman School of Medicine, 180 Madison Ave, New York, NY, 10016, USA. Jennifer.McNeely@nyulangone.org.ORCID 0000-0003-4601-6940

Funding

Project-003UG1DA013035 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Aimee N Campbell, Jennifer McNeely · 2015 to 2026
$130.3M
Western States Node of the National Drug Abuse Treatment Clinical Trials Network (TMS for CUD) UG1DA015815 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Keith N. Humphreys, Philip Todd Korthuis · 2015 to 2026
$24.6M
Greater Southern California Node of the Clinical Trials NetworkUG1DA049435 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YIH-ING HSER · 2019 to 2026
$16.7M
Project-008UG1DA049436 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jane M. Liebschutz, Erin L Winstanley · 2019 to 2026
$10.5M
Project-003UG1DA040317 · NIDA · DUKE UNIVERSITY · PI WU, LI-TZY · 2015 to 2019
$9.0M
National Drug Abuse Treatment Clinical Trials Network UG1DA013035National Drug Abuse Treatment Clinical Trials Network UG1DA015815National Drug Abuse Treatment Clinical Trials Network UG1DA040317National Drug Abuse Treatment Clinical Trials Network UG1DA049435National Drug Abuse Treatment Clinical Trials Network UG1DA049436NIDA NIH HHS UG1 DA013035NIDA NIH HHS UG1 DA015815NIDA NIH HHS UG1 DA040317NIDA NIH HHS UG1 DA049435NIDA NIH HHS UG1 DA049436
6 · The paper itself

Abstract

backgroundA majority of the 8.9 million Americans with opioid misuse have mild or no symptoms of opioid use disorder (OUD), but they may be at elevated risk of developing more severe OUD, overdose, or other health consequences of opioid use. The "Subthreshold Opioid Use Disorder Prevention"(STOP) Trial is evaluating a collaborative care intervention for risky opioid use in primary care. Here, we describe baseline characteristics of participants to understand their needs and assess the generalizability of the sample.

methodsRecruitment at five primary care sites spanned March 2021-May 2023. Adult patients who screened positive for subthreshold OUD (current illicit or non-medical opioid use without meeting DSM-5 criteria for moderate-severe OUD) were eligible. Baseline assessments measured self-reported demographic characteristics, other substance use, pain, and physical and mental health symptoms. Descriptive statistics summarize characteristics of the enrolled sample across sites.

resultsAmong the 202 participants, the majority identified as female (63.4%), white (70.8%), and non-Hispanic (96.5%), with mean age 55.7 (SD: 12.7) years. Nearly half (49.0%) had problem or high-risk use of prescription opioids, and most received a prescription for opioid medication in the past six months (74.8%). Many participants reported current problem use or high-risk use of alcohol (47.0%) or cannabis (31.2%). Approximately one-third endorsed mental health symptoms, including moderate-severe anxiety (35.6%), depression (31.2%), or sleep disturbance (29.7%), and 20.3% reported a past suicide attempt. In the prior six months, 14.7% had experienced a nonfatal overdose. Moderate-severe pain was reported by 63.4%, and 60.4% rated their general health as fair or poor.

conclusionsPatients with subthreshold OUD had high rates of polysubstance use and comorbidities that may present challenges to reducing risky opioid use. The STOP trial presents an opportunity to detect and address subthreshold OUD in a cohort with considerable medical and social needs, within primary care settings. CLINICAL TRIALS REGISTRATION: ClinicalTrials.gov NCT04218201.

Indexed as

Analgesics, OpioidOpioid-Related DisordersPrimary Health CareAdultComorbidityFemaleHumansMaleMiddle AgedUnited StatesAnalgesics, OpioidCollaborative careOpioid-related disordersPainPreventionPrimary careRisky opioid useSubstance use disorder

Identifiers

PMID40457116
PMCPMC12463776

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.