Evidence map›Paper›PMID 40457066›Full record

ArticleScientific reports2025

Modified starch as a new co-excipient in hydrophilic gels for prolonged drug delivery.

Justyna Kobryń, Aleksandra Witkowska, Bartosz Raszewski, Tomasz Zięba, Witold Musiał

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Justyna KobryńDepartment of Physical Chemistry and Biophysics, Wroclaw Medical University, Borowska 211A, 50-556, Wroclaw, Poland.
Aleksandra WitkowskaDepartment of Physical Chemistry and Biophysics, Wroclaw Medical University, Borowska 211A, 50-556, Wroclaw, Poland.
Bartosz RaszewskiDepartment of Food Storage and Technology, Faculty of Biotechnology and Food Science, Wroclaw University of Environmental and Life Sciences, Chełmońskiego 37, 51-630, Wroclaw, Poland.
Tomasz ZiębaDepartment of Food Storage and Technology, Faculty of Biotechnology and Food Science, Wroclaw University of Environmental and Life Sciences, Chełmońskiego 37, 51-630, Wroclaw, Poland.
Witold MusiałDepartment of Physical Chemistry and Biophysics, Wroclaw Medical University, Borowska 211A, 50-556, Wroclaw, Poland. witold.musial@umw.edu.pl.

Funding

Wroclaw Medical University SUBZ.D060.24.091
6 · The paper itself

Abstract

The hydrogels with methylene blue (MB), based on selected synthetic and semisynthetic polymers (SP), doped with citrate starch (CS), was evaluated successfully in the terms of MB release from polymeric matrix with prolonged release effect. The hydrophilic matrix in the hydrogel systems affects drug release, systemic absorption and therapeutic effect. The aim of the work was to investigate the use of citrate starch (CS) as an experimental drug carrier for cationic model drug-methylene blue (MB)-in the hydrogel formulation. The native potato starch was modified via esterification and crosslinking with 2.5 and 10.0% (w/w) of citric acid in 120 °C. The hydrogels of methylcellulose (MC), polyacrylic acid (Carbopol

Indexed as

Drug Delivery SystemsExcipientsHydrogelsStarchAcrylic ResinsCitric AcidDelayed-Action PreparationsDrug CarriersDrug LiberationHydrophobic and Hydrophilic InteractionsKineticsMethylene BlueSpectroscopy, Fourier Transform InfraredAcrylic ResinsCitric AcidDelayed-Action PreparationsDrug CarriersExcipientsHydrogelsMethylene BlueStarchCitrate potato starchFTIRHydrogelRelease kineticsSemisynthetic and synthetic polymersWeibull model

Identifiers

PMID40457066
PMCPMC12130450

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.