Evidence map›Paper›PMID 40457060›Full record

ArticleNature immunology2025

PD-1 receptor deficiency enhances CD30

Jing Xuan Lim, Tegan McTaggart, Seol Kyoung Jung, Katie J Smith, Gillian Hulme, Stephanie Laba, Yun Qi Ng, Amelia Williams, Rafiqul Hussain, Jonathan Coxhead and 8 more

Abstract read
In one paragraph

Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026
    Review
  3. Observational
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. CD39Frontiers in oncology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jing Xuan Lim *Biosciences Institute, Newcastle University, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0003-2288-3812
Tegan McTaggart *Biosciences Institute, Newcastle University, Newcastle University, Newcastle upon Tyne, UK.
Seol Kyoung JungNational Institute of Arthritis, Musculoskeletal and Skin, NIH, Bethesda, MD, USA.
Katie J SmithBiosciences Institute, Newcastle University, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0003-1034-1629
Gillian HulmeBiosciences Institute, Newcastle University, Newcastle University, Newcastle upon Tyne, UK.
Stephanie LabaBiosciences Institute, Newcastle University, Newcastle University, Newcastle upon Tyne, UK.
Yun Qi NgBiosciences Institute, Newcastle University, Newcastle University, Newcastle upon Tyne, UK.
Amelia WilliamsBiosciences Institute, Newcastle University, Newcastle University, Newcastle upon Tyne, UK.
Rafiqul HussainBiosciences Institute, Newcastle University, Newcastle University, Newcastle upon Tyne, UK.
Jonathan CoxheadBiosciences Institute, Newcastle University, Newcastle University, Newcastle upon Tyne, UK.
Ioana CosgareaNIHR, Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK.
Catherine ArdenBiosciences Institute, Newcastle University, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0002-3642-3182
Jérémie NsengimanaPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0002-3603-4208
Penny LovatNIHR, Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK.
Graham AndersonDepartment of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-2917-4085
Hong-Wei SunNational Institute of Arthritis, Musculoskeletal and Skin, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-9765-6505
Arian LaurenceTranslational Gastroenterology Unit, Nuffield School of Medicine, Oxford University, Oxford, UK.
Shoba AmarnathBiosciences Institute, Newcastle University, Newcastle University, Newcastle upon Tyne, UK. shoba.amarnath@newcastle.ac.uk.ORCID http://orcid.org/0000-0001-8081-8432

Funding

Academy of Medical Sciences SBF003_1129_6LEO Pharma Research Foundation LF-SE-23-800015National Centre for the Replacement Refinement and Reduction of Animals in Research (NC3Rs) NC/W002043/1RCUK | Medical Research Council (MRC) MR/T015586/1
6 · The paper itself

Abstract

Regulatory T (T

Indexed as

Ki-1 AntigenMelanomaProgrammed Cell Death 1 ReceptorT-Lymphocytes, RegulatoryAnimalsCell Line, TumorHumansMiceMice, Inbred C57BLMice, KnockoutSignal TransductionSTAT5 Transcription FactorTumor MicroenvironmentKi-1 AntigenPdcd1 protein, mouseProgrammed Cell Death 1 ReceptorSTAT5 Transcription Factor

Identifiers

PMID40457060
PMCPMC12208868

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.