ArticleMolecular neurobiology2025
Comparative Effects of Co-administration of Lactobacillus casei and Bifidobacterium breve vs. Monotherapy on Hippocampal Neurodegeneration in a D-Galactose-Induced Aging Model.
Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Ellagitannin Metabolite Urolithin D Ameliorates Cognitive Function and Behavioral Performance in Aging Mice Partially via AMPK/PGC-1α/SIRT3-Dependent Regulation of Mitophagy-Related Molecular Machinery.Molecular neurobiology · 2026Article
- Potential of intranasal caffeine as a delivery route for treating glutamate-linked hippocampal neurodegeneration by activating endogenous antioxidant defenses.Molecular biology reports · 2026Article
- Chasing the FoxO in Metabolic Disorders: Novel Considerations for Oxidative Stress, Programmed Cell Death, Wnt, and the Gut Microbiome.Antioxidants (Basel, Switzerland) · 2026Review
- Osteoarthritis and dementia: contrasting disorders driven by mutual pathways of autophagy, mTOR, GLP-1, AMPK, Wnt, and WISP1.Expert review of clinical pharmacology · 2026Review
- Agitation, Alzheimer's disease, and autophagy: mechanistic insights into aging pathways, gut microbiome, and artificial intelligence.Frontiers in immunology · 2026Review
- Running out the clock: Circadian rhythm dysfunction in cognitive disease.International review of neurobiology · 2026Review
- Probiotics intervention reduces oxidative stress-driven myocardial injury.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been shown that gut dysbiosis, a hallmark of aging, participates in age-related neurodegenerative conditions. Consumption of probiotics has favorable effects not only on gut hemostasis but also on the brain via the microbiota-gut-brain axis. Ongoing research aims to identify the most suitable probiotic or combination of probiotics tailored to each specific condition. Hence, the present study tested the effects of combination therapy of Lactobacillus casei (L. casei) and Bifidobacterium breve (B. breve) on the memory and some potential molecular mechanisms of a mouse aging model. Male Balb/C mice were subcutaneously injected with D-galactose to induce aging and orally supplemented with L. casei and B. breve for 8 weeks. The results showed that treatment with L. casei, B. breve, or their co-administration during the aging process improves the impairment of alternation and locomotion behavior in a Y-maze test. Gene expression analysis revealed that consumption of L. casei and B. breve upregulates α-KL, Sirt1, HO-1, and Nrf2 and suppresses IL-1β and IL-18 gene expression in the right hippocampus. Probiotics treatment also reduced the oxidative stress biomarker malondialdehyde (MDA), increased superoxide dismutase (SOD), and mitigated histopathological changes and neurodegeneration in the left hippocampus. Moreover, the level of fluorescent intensity of BDNF was higher in probiotics-receiving groups. Considerably, our study reveals that L. casei shows better performance compared to B. breve, and the combination therapy appears to exhibit a synergistic effect. Together, these findings suggest that a combination of L. casei and B. breve may have better therapeutic potential than monotherapy for controlling oxidative stress and neurodegeneration in aging.
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Registered trials
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