Evidence map›Paper›PMID 40456992›Full record

ArticleAesthetic plastic surgery2025

Efficacy and Tolerability Assessment of Deoxycholic Acid Injectable Solution for Reduction of Submental Fat Among the Iranian Population.

Taraneh Yazdanparast, Mansour Nassiri Kashani, Aniseh Samadi, Araz Sabzvari, Hamidreza Kafi, Fatemeh Amiri, Alireza Firooz

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Article in Aesthetic plastic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Taraneh YazdanparastCenter for Research and Training in Skin Diseases and Leprosy [CRTSDL], Tehran University of Medical Sciences [TUMS], # 415 Taleqani Ave, Tehran, Iran.
Mansour Nassiri KashaniCenter for Research and Training in Skin Diseases and Leprosy [CRTSDL], Tehran University of Medical Sciences [TUMS], # 415 Taleqani Ave, Tehran, Iran.
Aniseh SamadiCenter for Research and Training in Skin Diseases and Leprosy [CRTSDL], Tehran University of Medical Sciences [TUMS], # 415 Taleqani Ave, Tehran, Iran.
Araz SabzvariCinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Hamidreza KafiMedical Department, Orchid Pharmed Company, Tehran, Iran.
Fatemeh AmiriCenter for Research and Training in Skin Diseases and Leprosy [CRTSDL], Tehran University of Medical Sciences [TUMS], # 415 Taleqani Ave, Tehran, Iran.
Alireza FiroozCenter for Research and Training in Skin Diseases and Leprosy [CRTSDL], Tehran University of Medical Sciences [TUMS], # 415 Taleqani Ave, Tehran, Iran. firozali@tums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe purpose of this study was the safety and efficacy assessment of Embella

methodsTwenty patients were included in this before-and-after study. One to three subcutaneous injections of maximum 2 ml of Embella

resultsAt least one-grade improvement on the CR-SMFRS was seen in 79% and 62.5% at weeks 4 and 12 after the last injection. A significant decrease was observed in the median CR-SMFRS at weeks 4 and 12 (p-values<0.001 & 0.004). The median diameter of SMF decreased significantly from 1.85 cm to 1.4 and 1.45 cm at weeks 4 and 12 (p-values<0.001). The mean satisfaction scores were 7.63 and 7.43 out of 10. Adverse effects were mild to moderate and included tenderness, pain, swelling, and numbness at the injection site as well as globus sensation and cough which lasted between 2 days and 2 weeks and completely resolved at week 4.

conclusionsEmbella LEVEL OF EVIDENCE II: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Indexed as

Deoxycholic AcidSubcutaneous FatAdultCohort StudiesCosmetic TechniquesFemaleFollow-Up StudiesHumansInjections, SubcutaneousIranMaleMiddle AgedPatient SatisfactionRisk AssessmentTreatment OutcomeYoung AdultDeoxycholic AcidDeoxycholic acidSMFSubmental fat

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.