Evidence map›Paper›PMID 40456949›Full record

ArticleCommunications engineering2025

Acoustic hologram-enabled simultaneous multi-target blood-brain barrier opening (AH-SiMBO).

Xinya Yao, Xiangkun Piao, Shulong Hong, Chenyu Ji, Mingyu Wang, Yan Wei, Zhouyang Xu, Jia-Ji Pan, Yanbo Pei, Bingbing Cheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xinya YaoTranslational Research in Ultrasound Theranostics Laboratory, School of Biomedical Engineering, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0009-0000-6522-3502
Xiangkun PiaoTranslational Research in Ultrasound Theranostics Laboratory, School of Biomedical Engineering, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0009-0004-1026-9334
Shulong HongInstitute of Modern Optics, School of Physics, Harbin Institute of Technology, Harbin, China.
Chenyu JiTranslational Research in Ultrasound Theranostics Laboratory, School of Biomedical Engineering, ShanghaiTech University, Shanghai, China.
Mingyu WangTranslational Research in Ultrasound Theranostics Laboratory, School of Biomedical Engineering, ShanghaiTech University, Shanghai, China.
Yan WeiTranslational Research in Ultrasound Theranostics Laboratory, School of Biomedical Engineering, ShanghaiTech University, Shanghai, China.
Zhouyang XuTranslational Research in Ultrasound Theranostics Laboratory, School of Biomedical Engineering, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0009-0003-8653-4977
Jia-Ji PanTranslational Research in Ultrasound Theranostics Laboratory, School of Biomedical Engineering, ShanghaiTech University, Shanghai, China.
Yanbo PeiInstitute of Modern Optics, School of Physics, Harbin Institute of Technology, Harbin, China. peiyanbo@hit.edu.cn.ORCID http://orcid.org/0000-0001-5849-9340
Bingbing ChengTranslational Research in Ultrasound Theranostics Laboratory, School of Biomedical Engineering, ShanghaiTech University, Shanghai, China. chengbb@shanghaitech.edu.cn.ORCID http://orcid.org/0000-0002-1336-4781

Funding

National Natural Science Foundation of China (National Science Foundation of China) 62075048Natural Science Foundation of Shanghai (Natural Science Foundation of Shanghai Municipality) 23ZR1442000
6 · The paper itself

Abstract

Focused ultrasound-induced blood-brain barrier (BBB) opening enables targeted brain drug delivery. However, achieving simultaneous multi-target BBB opening across various depths and regions remains challenging and cost-prohibitive. Here we address these challenges by employing encoded acoustic holograms combined with a single-element plane-wave transducer to generate precise focused acoustic fields. The holograms designed using an iterative angular spectrum approach and fabricated via 3D printing produce single or multiple foci at different depths and regions, which are confirmed by simulations and hydrophone-based measurements. Beam steering capability is demonstrated and further validated in vivo. We design a hologram with less than 10% variation in amplitude across different foci and successfully achieve biplane multi-target ( ≥3) BBB opening in the bilateral hippocampus and medial septum of mice in a single sonication session with no adverse effects. This innovative acoustic holographic approach for simultaneous multi-target BBB opening is time-efficient and cost-effective, presenting broad potential applications in brain drug delivery and neuromodulation.

Identifiers

PMID40456949
PMCPMC12130547

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.