Trial reportScientific reports2025
Effects of external diaphragmatic pacing with neurally adjusted ventilatory assist on diaphragm function in AECOPD patients.
Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk factors for diaphragmatic dysfunction in mechanically ventilated patients: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Effectiveness of electrical stimulation for postoperative rehabilitation of lung cancer: a systematic review and meta-analysis.Journal of thoracic disease · 2026Article
- Application of bedside ultrasound assessment of diaphragmatic function in preparing tracheostomised patients for ventilator liberation and decannulation: a narrative review.Journal of thoracic disease · 2026Review
- Beyond blood gases: diaphragm-guided sequential non-invasive ventilation for COPD with type II respiratory failure.Frontiers in medicine · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
Abstract
Diaphragm dysfunction, a prevalent complication in mechanically ventilated patients, is strongly associated with prolonged weaning periods and increased mortality rates. Neurally adjusted ventilatory assist (NAVA), which synchronizes ventilator support with neural respiratory drive through diaphragmatic electromyography monitoring, has demonstrated efficacy in preserving diaphragm contractility. Complementary to this, the external diaphragmatic pacing (EDP) mitigates ventilation-induced diaphragmatic atrophy through targeted phrenic nerve stimulation. However, the synergistic potential of the NAVA + EDP combination therapy in acute exacerbations of chronic obstructive pulmonary disease (AECOPD) remains unexplored. This prospective randomized trial enrolled 60 mechanically ventilated patients with AECOPD, who were equally allocated into three groups (n = 20 per group): conventional pressure support ventilation (PSV), neurally adjusted ventilatory assist (NAVA), and NAVA combined with external diaphragm pacing (NAVA + EDP). The primary outcome was diaphragmatic function, assessed using two ultrasonographic parameters: diaphragmatic excursion (DE) and diaphragm thickness fraction (DTF). Secondary outcomes included the following: (a) respiratory mechanics parameters, including electrical activity of the diaphragm (EAdi), plateau pressure (Pplat), static lung compliance (Cst), and airway resistance (Raw); (b) gas exchange indices, such as partial pressure of arterial carbon dioxide (PaCO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.