ArticleNPJ microgravity2025
Understanding the relationship between intracranial pressure and spaceflight associated neuro-ocular syndrome (SANS): a systematic review.
Article in NPJ microgravity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Physiological cerebrospinal fluid interactions between brain and eye structures are altered after long-duration spaceflight.Experimental physiology · 2026Article
- Ophthalmic and Visual System Changes in Human Spaceflight: A Review of Mechanisms, Measurement, and Countermeasures.Journal of clinical medicine · 2026Review
- Ocular health in outer space and beyond gravity: A minireview.World journal of clinical cases · 2026Review
- AstroOphthalmology: Basic and Pathophysiological Concepts of Space-Induced Ocular Changes.Eye and brain · 2026Review
- A systematic review of the cerebrovascular adaptations following exposure to spaceflight or ground-based analogs: lessons from human and animal studies.NPJ microgravity · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuro-ocular changes, such as globe flattening, optic disc edema or chorioretinal folds, are a major worry when considering astronaut health. These findings are now known as Spaceflight Associated Neuro-Ocular Syndrome. This systematic review aims to discuss the possible mechanisms involved in the pathogenesis of this syndrome. Contemplating the different reports regarding the impact of intracranial pressure (ICP), cardiovascular system, hypercapnia or glymphatic system, we hypothesize that a relationship exists between variations in ICP and SANS development. A literature search of five databases was conducted using the PICO model. Twenty studies were subsequently included, and two main theories discussed. The first suggests that cerebrospinal fluid (CSF) shifts can lead to a rise in ICP, while the second supports the importance of CSF compartmentalization, independently of ICP variation. These hypotheses are not mutually exclusive and environmental factors may also be essential for the development of this syndrome.
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Registered trials
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