Evidence map›Paper›PMID 40456751›Full record

ArticleScientific data2025

The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry.

Sidhant Chopra, Carrisa V Cocuzza, Connor Lawhead, Jocelyn A Ricard, Loïc Labache, Lauren M Patrick, Poornima Kumar, Arielle Rubenstein, Julia Moses, Lia Chen and 7 more

Abstract readDataset
In one paragraph

Article in Scientific data, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Sidhant Chopra *Department of Psychology, Yale University, New Haven, CT, USA.
Carrisa V Cocuzza *Department of Psychology, Yale University, New Haven, CT, USA.
Connor Lawhead *Department of Psychology, Yale University, New Haven, CT, USA.
Jocelyn A RicardDepartment of Psychology, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-9605-9389
Loïc LabacheDepartment of Psychology, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-5733-0743
Lauren M PatrickDepartment of Psychology, Yale University, New Haven, CT, USA.
Poornima KumarDepartment of Psychiatry, Harvard Medical School, Boston, USA.
Arielle RubensteinDepartment of Psychology, Yale University, New Haven, CT, USA.
Julia MosesDepartment of Psychology, Yale University, New Haven, CT, USA.
Lia ChenDepartment of Psychology, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0001-9172-9339
Crystal BlankenbakerInstitute for Technology in Psychiatry, McLean Hospital, Boston, USA.
Bryce GillisDepartment of Psychiatry, Harvard Medical School, Boston, USA.
Laura T GermineDepartment of Psychiatry, Harvard Medical School, Boston, USA.
Ilan Harpaz-RotemDepartment of Psychology, Yale University, New Haven, CT, USA.
B T Thomas YeoCentre for Sleep and Cognition & Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Justin T BakerDepartment of Psychiatry, Harvard Medical School, Boston, USA.ORCID http://orcid.org/0000-0002-6629-2195
Avram J HolmesDepartment of Psychiatry, Brain Health Institute, Rutgers University, Piscataway, NJ, USA. avram.holmes@rutgers.edu.ORCID http://orcid.org/0000-0001-6583-803X

Funding

SCHIZOPHRENIA: A NEUROPSYCHIATRIC PERSPECTIVET32MH019112 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 1990 to 2024
$6.2M
Functional genomics of the human connectome in psychiatric illnessR01MH120080 · NIMH · YALE UNIVERSITY · PI AVRAM J HOLMES, Thomas Boon Thye Yeo · 2019 to 2026
$4.8M
Integrative analysis of genomics and imaging data from the BRAIN Initiative and other public data sourcesRF1MH123245 · NIMH · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER, HOLMES, AVRAM J · 2021 to 2021
$1.3M
NIMH NIH HHS R01 MH120080NIMH NIH HHS RF1 MH123245NIMH NIH HHS T32 MH019112U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH120080U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH123245
6 · The paper itself

Abstract

An important aim in psychiatry is to establish valid and reliable associations linking profiles of brain functioning to clinically relevant symptoms and behaviors across patient populations. To advance progress in this area, we introduce an open dataset containing behavioral and neuroimaging data from 241 individuals aged 18 to 70, comprising 148 individuals meeting diagnostic criteria for a broad range of psychiatric illnesses and a healthy comparison group of 93 individuals. These data include high-resolution anatomical scans, multiple resting-state, and task-based functional MRI runs. Additionally, participants completed over 50 psychological and cognitive assessments. Here, we detail available behavioral data as well as raw and processed MRI derivatives. Associations between data processing and quality metrics, such as head motion, are reported. Processed data exhibit classic task activation effects and canonical functional network organization. Overall, we provide a comprehensive and analysis-ready transdiagnostic dataset to accelerate the identification of illness-relevant features of brain functioning, enabling future discoveries in basic and clinical neuroscience.

Indexed as

BrainConnectomeMental DisordersAdolescentAdultAgedBehaviorFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPsychiatryYoung Adult

Identifiers

PMID40456751
PMCPMC12130183

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.