Evidence map›Paper›PMID 40456688›Full record

ArticleJournal of biomedical research2025

Overexpression of

Haiying Han, Tianqi Shen, Tingting Zhou, Yixuan Yang, Weiyi Toy, Yin Yin Choo, Fan Lin, Yoon Pin Lim

Abstract read
In one paragraph

Article in Journal of biomedical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Haiying HanDepartment of Nursing, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310000, China.
Tianqi ShenDepartment of Cell Biology, School of Basic Medical Sciences; Institute for Brain Tumors & Key Laboratory of Rare Metabolic Diseases; The Affiliated Cancer Hospital, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Tingting ZhouDepartment of Cell Biology, School of Basic Medical Sciences; Institute for Brain Tumors & Key Laboratory of Rare Metabolic Diseases; The Affiliated Cancer Hospital, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Yixuan YangDepartment of Cancer Biology and Innovation, Guoke Ningbo Life and Health Industry Research Institute, Ningbo, Zhejiang 315000, China.
Weiyi ToyDepartment of Cancer Biology and Innovation, Guoke Ningbo Life and Health Industry Research Institute, Ningbo, Zhejiang 315000, China.
Yin Yin ChooDepartment of Cancer Biology and Innovation, Guoke Ningbo Life and Health Industry Research Institute, Ningbo, Zhejiang 315000, China.
Fan LinDepartment of Cell Biology, School of Basic Medical Sciences; Institute for Brain Tumors & Key Laboratory of Rare Metabolic Diseases; The Affiliated Cancer Hospital, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Yoon Pin LimDepartment of Cancer Biology and Innovation, Guoke Ningbo Life and Health Industry Research Institute, Ningbo, Zhejiang 315000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC) is a prevalent and devastating disease with a poor prognosis. The lack of biomarkers for early detection and effective targeted therapeutics for GC patients represents two major challenges. Through isobaric tags for relative and absolute quantitation (iTRAQ) coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) phosphoproteomic analysis of 14 GC and gastric epithelial cell lines, we discovered the discoidin domain receptor tyrosine kinase 1 (DDR1) as a top potential drug target out of 40 tyrosine kinases detected along with over 1000 phosphoproteins profiled. The DDR1 protein and mRNA levels were upregulated in GC cells concurrent with

Indexed as

7rhDDR1gastric cancerHippo pathwayiTRAQphosphoproteomic analysis

Identifiers

PMID40456688
PMCPMC12481679

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.