Evidence map›Paper›PMID 40456684›Full record

ArticleNeurogastroenterology and motility2025

Neuropathic Gastroduodenal Disorders Can Be Diagnosed by Non-Invasive Body Surface Gastric Mapping: A Comparison With Antroduodenal Manometry.

Christian Sadaka, Binghong Xu, Alain J Benitez, Carolyn M Orians, Corey Bowerman, Jordan Dourlain, Beth Skaggs, Kimberly G Konka, Lexi Roshkovan, Gayl Humphrey and 5 more

Abstract readComparative Study
In one paragraph

Article in Neurogastroenterology and motility, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Christian SadakaGastroenterology, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0009-0003-5665-5743
Binghong XuGastroenterology, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Pennsylvania, USA.
Alain J BenitezGastroenterology, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Pennsylvania, USA.
Carolyn M OriansGastroenterology, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Pennsylvania, USA.
Corey BowermanGastroenterology, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Pennsylvania, USA.
Jordan DourlainGastroenterology, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Pennsylvania, USA.
Beth SkaggsGastroenterology, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Pennsylvania, USA.
Kimberly G KonkaGastroenterology, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Pennsylvania, USA.
Lexi RoshkovanGastroenterology, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Pennsylvania, USA.
Gayl HumphreyDepartment of Surgery, The University of Auckland, Auckland, New Zealand.ORCID https://orcid.org/0000-0002-2837-5707
Stefan CalderDepartment of Surgery, The University of Auckland, Auckland, New Zealand.
Gabriel SchambergDepartment of Surgery, The University of Auckland, Auckland, New Zealand.ORCID https://orcid.org/0000-0002-4188-9614
Greg O'GradyDepartment of Surgery, The University of Auckland, Auckland, New Zealand.ORCID https://orcid.org/0000-0002-5998-1080
Armen A GharibansPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-9139-4740
Hayat MousaGastroenterology, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Pennsylvania, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntroduodenal manometry (ADM) is the gold standard for diagnosing myopathy and neuropathy in patients with upper gastrointestinal (GI) disorders. However, ADM is invasive and costly. Body surface gastric mapping (BSGM) has emerged as a non-invasive test to assess gastric function. This study evaluates the correlation between BSGM and ADM in children.

methodsClinically indicated ADM was performed using high-resolution water-perfused motility catheters, with simultaneous BSGM. Real-time symptoms were tracked using a validated symptom logging app at 15-min intervals, and Nausea Severity Scale (NSS) scores were recorded. Protocols involved a 2 h fast, provocative testing, a meal, and over 1 h of post-prandial recordings. ADM tracings were categorized into neuropathy, myopathy, post-prandial hypomotility, or normal. BSGM metrics included principal gastric frequency, BMI-adjusted amplitude, and Rhythm Index. Gastric emptying data were also evaluated.

resultsFifteen subjects were recruited (13 female; ages 10-19 years, BMI 20.6 ± 3.5 kg/m

conclusionDysrhythmic BSGM phenotype reliably identified gastrointestinal neuropathy with identical results to ADM, with significant correlations to nausea and bloating severity. This study supports considering BSGM as an actionable biomarker when performing ADM is not feasible.

Indexed as

Duodenal DiseasesGastrointestinal DiseasesManometryAdolescentChildFemaleGastric EmptyingGastrointestinal MotilityHumansMaleStomachYoung Adultantral hypomotilityantroduodenal manometrybody surface gastric mappingfunctional dyspepsiagastroparesisneuropathy

Identifiers

PMID40456684
PMCPMC12435801

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.