ArticleeNeuro2025
Chronic Intraventricular Cannulation for the Study of Glymphatic Transport.
Article in eNeuro, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Article
- Article
- Intracranial pressure management in severe intraventricular hemorrhage: A minireview.World journal of critical care medicine · 2026Review
- Impact of infusion conditions and anesthesia on CSF tracer dynamics in mouse brain.Fluids and barriers of the CNS · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Glymphatic transport in rodents has primarily been studied using cisterna magna cannulation (CMC), a minimally invasive method for cerebrospinal fluid (CSF) tracers infusion. However, CMC is suboptimal due to the lack of bony structures to stabilize the cannula, leading to potential movement artifacts. Here, we present an alternative approach involving chronic cannulation of the lateral ventricles of mice for CSF tracer delivery. A direct comparison demonstrated that intraventricular cannulation (IVC) reproduces CMC results in vivo, including perivascular labeling of the middle cerebral artery, which was further confirmed by ex vivo analysis. IVC enables tracer infusion in awake mice, facilitating glymphatic transport studies in conjunction with behavioral assessments that were previously unattainable. Additionally, IVC supports repeated infusions in awake animals, offering the potential to reduce the number of experimental animals required. This study establishes IVC as a robust alternative for studying glymphatic transport and associated physiological processes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.