Evidence map›Paper›PMID 40456612›Full record

ArticleeNeuro2025

Tolerance in Thalamic Paraventricular Nucleus Neurons Following Chronic Treatment of Animals with Morphine.

Omar Koita, Joseph J Lebowitz, John T Williams

Abstract read
In one paragraph

Article in eNeuro, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Omar KoitaVollum Institute, Oregon Health & Science University, Portland, Oregon 97239.
Joseph J LebowitzVollum Institute, Oregon Health & Science University, Portland, Oregon 97239.
John T WilliamsVollum Institute, Oregon Health & Science University, Portland, Oregon 97239 williamj@ohsu.edu.ORCID https://orcid.org/0000-0002-0647-6144

Funding

COCAINE: EFFECTS ON SINGLE NEURONSR01DA004523 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 1987 to 2025
$7.6M
Mechanistic description of tolerance/withdrawal from opioids in the paraventricular nucleus of the thalamusF99NS129176 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI KOITA, OMAR · 2022 to 2023
$96k
NIDA NIH HHS R01 DA004523NINDS NIH HHS F99 NS129176
6 · The paper itself

Abstract

Neurons in the paraventricular nucleus of the thalamus (PVT) integrate visceral and limbic inputs and project to multiple brain regions to bias behavior toward aversive or defensive states. This study examines MOR signaling in anterior PVT neurons in brain slices from untreated and morphine-treated animals. Imaging in a MOR-Cre reporter rat revealed extensive expression in aPVT cells, and the application of [Met]

Indexed as

Analgesics, OpioidDrug ToleranceMidline Thalamic NucleiMorphineNeuronsAmygdalaAnimalsMaleNeural PathwaysNucleus AccumbensPrefrontal CortexRatsRats, Sprague-DawleyReceptors, Opioid, muAnalgesics, OpioidMorphineReceptors, Opioid, mudesensitizationmorphineneuronal excitabilityopioidstolerancewithdrawal

Identifiers

PMID40456612
PMCPMC12177709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.