SynthesisRenal failure2025
Effect of nutritional intervention combined with resistance exercise on clinical indicators of patients with sarcopenia in maintenance hemodialysis: a systematic review and meta-analysis.
Synthesis in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Screening effect of phase angle and calf circumference in different stages of sarcopenia in patients with maintenance hemodialysis.BMC musculoskeletal disorders · 2026Article
- The Influence of Aerobic and Strength Training on Oxidative Stress and Antioxidant Status in Hemodialysis Patients: A Randomized Controlled Trial.Health science reports · 2026Article
- Sarcopenia in older adults: Prevalence and links to depression and physical activity.World journal of psychiatry · 2026Article
- Novel prediction equations for appendicular skeletal muscle mass in hemodialysis patients: referenced against bioelectrical impedance analysis.Frontiers in nutrition · 2026Article
- Sarcopenia in rheumatic and musculoskeletal diseases: pathophysiology, diagnosis, and management.Rheumatology international · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to evaluate the effects of exercise therapy combined with nutritional intervention on muscle strength, muscle mass, and physical function in maintenance hemodialysis (MHD) patients with sarcopenia (SP) through a systematic review and meta-analysis.
methodsWe searched multiple databases for RCTs published up to November 2024. Inclusion criteria: patients aged ≥18 with end-stage renal disease receiving MHD and diagnosed with SP; experimental group receiving combined exercise and nutrition intervention, and control group receiving either intervention alone; outcome measures including muscle strength, muscle mass, and physical function. Meta-analysis was performed using Stata 15.1.
resultsNine high-quality RCTs involving 513 MHD-SP patients (256 experimental, 257 control) were included. The combined intervention group showed significantly greater improvements in handgrip strength (WMD = 3.78, 95% CI: 2.02-5.53), leg power score (WMD = 5.52, 95% CI: 1.47-9.58), skeletal muscle index (WMD = 0.82, 95% CI: 0.62-1.03), lean body mass (WMD = 2.53, 95% CI: 0.45-4.61), walking speed (WMD = 0.11, 95% CI: 0.01-0.22), 6-minute walk test (WMD = 41.37, 95% CI: 20.16-62.58), and 30-second sit-to-stand test (WMD = 3.37, 95% CI: 1.67-5.07). Heterogeneity analysis showed I
conclusionCombined exercise therapy and nutritional intervention significantly improve muscle strength, mass, and physical function in MHD patients with sarcopenia, offering important clinical benefits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.