Evidence map›Paper›PMID 40456509›Full record

ArticleMathematical biosciences2025

Bistability between acute and chronic states in a Model of Hepatitis B Virus Dynamics.

Nazia Afrin, Stanca M Ciupe, Jessica M Conway, Hayriye Gulbudak

Abstract read
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In one paragraph

Article in Mathematical biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nazia AfrinDepartment of Mathematics, University of Louisiana at Lafayette, 104 E. University Circle Lafayette, Lafayette, 70503, LA, USA.
Stanca M CiupeDepartment of Mathematics and Virginia Tech Center for the Mathematics of Biosystems, Virginia Tech, Blacksburg, VA, USA.
Jessica M ConwayDepartment of Mathematics and Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA, USA.
Hayriye GulbudakDepartment of Mathematics, University of Louisiana at Lafayette, 104 E. University Circle Lafayette, Lafayette, 70503, LA, USA. Electronic address: hayriye.gulbudak@louisiana.edu.

Funding

Modeling Viral and T Lymphocyte DynamicsR01OD011095 · OD · TRIAD NATIONAL SECURITY, LLC · PI PERELSON, ALAN S · 2012 to 2024
$5.0M
Collaborative Research: DMS/NIGMS 1: Identifiability investigation of Multi-scale Models of Infectious DiseasesR01GM152743 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI CIUPE, STANCA M. · 2023 to 2025
$600k
SIV cervicovaginal transmission dynamicsR21AI143443 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI CONWAY, JESSICA M · 2020 to 2021
$427k
NIAID NIH HHS R21 AI143443NIGMS NIH HHS R01 GM152743NIH HHS R01 OD011095
6 · The paper itself

Abstract

Understanding the mechanisms responsible for different clinical outcomes following hepatitis B infection requires a systems investigation of dynamical interactions between the virus and the immune system. To help elucidate mechanisms of protection and those responsible from transition from acute to chronic disease, we developed a deterministic mathematical model of hepatitis B infection that accounts for cytotoxic immune responses resulting in infected cell death, non-cytotoxic immune responses resulting in infected cell cure and protective immunity from reinfection, and cell proliferation. We analyzed the model and presented outcomes based on three important disease markers: the basic reproduction number R

Indexed as

Hepatitis BHepatitis B, ChronicHepatitis B virusModels, BiologicalAcute DiseaseBasic Reproduction NumberHumansAcute infectionBistabilityChronic infectionHepatitis B virusHopf bifurcationMathematical modeling

Identifiers

PMID40456509
PMCPMC12245406

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.