Evidence map›Paper›PMID 40456431›Full record

Trial reportAmerican heart journal2025

Systolic performance of the single ventricle, exercise capacity, and endothelial function in pediatric Fontan patients.

Flora Nuñez Gallegos, Daniel Bernstein, Rajesh Punn, Jin Long, Katie Jo Stauffer, Kelly Thorson, Sharon Chen, Mavis C Lui, Inger Olson, Jonathan Myers and 2 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American heart journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04195451 (RE-ENERGIZE FONTAN), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04195451 nacompletednot on this map

RE-ENERGIZE FONTAN: A RandomizEd Exercise INtERvention DesiGned to MaximIZE Fitness in Pediatric FONTAN Patients

TypeinterventionalSponsorStanford UniversityRan2020 to 2026Enrolled150ConditionsSingle-ventricleArmsLive-Video-Supervised Exercise Intervention, Usual Care then Live-Video Supervised Exercise Intervention
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Flora Nuñez GallegosStanford University School of Medicine, Stanford, CA 291 Campus Drive, Stanford, CA. Electronic address: flora.nunezgallegos@ucsf.edu.
Daniel BernsteinStanford University School of Medicine, Stanford, CA 291 Campus Drive, Stanford, CA.
Rajesh PunnStanford University School of Medicine, Stanford, CA 291 Campus Drive, Stanford, CA.
Jin LongStanford University School of Medicine, Stanford, CA 291 Campus Drive, Stanford, CA.
Katie Jo StaufferStanford University School of Medicine, Stanford, CA 291 Campus Drive, Stanford, CA.
Kelly ThorsonStanford University School of Medicine, Stanford, CA 291 Campus Drive, Stanford, CA.
Sharon ChenStanford University School of Medicine, Stanford, CA 291 Campus Drive, Stanford, CA.
Mavis C LuiStanford University School of Medicine, Stanford, CA 291 Campus Drive, Stanford, CA.
Inger OlsonStanford University School of Medicine, Stanford, CA 291 Campus Drive, Stanford, CA.
Jonathan MyersStanford University School of Medicine, Stanford, CA 291 Campus Drive, Stanford, CA.
Latha PalaniappanStanford University School of Medicine, Stanford, CA 291 Campus Drive, Stanford, CA.
Seda TierneyStanford University School of Medicine, Stanford, CA 291 Campus Drive, Stanford, CA.

Funding

RE-ENERGIZE FONTAN - RandomizEd Exercise INtERvention desiGned to MaximIZE Fitness in Pediatric FONTAN patientsR33HL146775 · NHLBI · STANFORD UNIVERSITY · PI BERNSTEIN, DANIEL, PALANIAPPAN, LATHA P · 2021 to 2024
$2.8M
META - Mentor, Educate, Train, Advocate: Patient Oriented Researchers in Cardiometabolic DiseaseK24HL150476 · NHLBI · STANFORD UNIVERSITY · PI Latha P Palaniappan · 2020 to 2026
$846k
RE-ENERGIZE FONTAN - RandomizEd Exercise INtERvention desiGned to MaximIZE Fitness in Pediatric FONTAN patientsR61HL146775 · NHLBI · STANFORD UNIVERSITY · PI BERNSTEIN, DANIEL, PALANIAPPAN, LATHA P · 2020 to 2020
$753k
NHLBI NIH HHS K24 HL150476NHLBI NIH HHS R33 HL146775NHLBI NIH HHS R61 HL146775
6 · The paper itself

Abstract

backgroundBy age 40, roughly half of the individuals with Fontan circulation will have died or undergone heart transplantation. Poor exercise capacity and endothelial dysfunction accelerate disease progression.

objectiveThis study aims to assess the systolic function of the single ventricle (SV) in pediatric Fontan patients entering an exercise intervention (RE-ENERGIZE FONTAN) and how it is associated with exercise capacity and endothelial function.

methodsThis cohort comes from an ongoing randomized trial in Fontan patients, using live video conferencing for supervised exercise. Participants (ages 8-19) cleared for exercise underwent 2D/3D echocardiograms, cardiopulmonary testing, and endothelial function (RHI). 2D longitudinal strain (LS, right ventricle), 2D global longitudinal strain (GLS, left ventricle), and circumferential strain were measured with TomTec, and 3D ejection fraction (3D-EF) and 3D-GLS were calculated.

resultsWe have enrolled 114 Fontan patients. Median age was 12.7 years (IQR 10.2, 15.6). The median time from Fontan operation was 8.8 years (IQR 6.2, 12.0). Fifty-seven patients (50%) had a single right ventricle. SV systolic performance measures were: 2D-LS/GLS -15.6% ± 4.19%, circumferential strain was -18.7% ± 6.83%, 3D-EF 49.9% ± 7.26%, and 3D-GLS -16.8% ± 4.37%. Peak VO

conclusionsIn this cohort of pediatric Fontan patients, SV systolic function was diminished at baseline, and there was a direct correlation between 2D strain and 3D-EF with percent predicted peak VO CLINICAL TRIAL NUMBER: NCT04195451.

Indexed as

Endothelium, VascularExercise ToleranceFontan ProcedureHeart Defects, CongenitalHeart VentriclesUniventricular HeartAdolescentChildCross-Over StudiesEchocardiography, Three-DimensionalExercise TestFemaleHumansMaleStroke VolumeSystole

Identifiers

PMID40456431
PMCPMC13224821

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.