Evidence map›Paper›PMID 40456289›Full record

ArticleNeuropediatrics2025

Nausea, Vertical Gaze Palsy, and Excessive Sleep: An Unusual Presentation of Pediatric AQP4-Antibody Positive Neuromyelitis Optica Spectrum Disorder.

Tatjana A Oberholzer, Leonie Plastina, David Wille, Selma Sirin, Annette Hackenberg

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tatjana A OberholzerDepartment of Pediatric Neurology, University Children's Hospital, Zürich, Switzerland.
Leonie PlastinaDepartment of Pediatric Neurology, University Children's Hospital, Zürich, Switzerland.
David WilleDepartment of Pediatric Neurology, University Children's Hospital, Zürich, Switzerland.
Selma SirinDepartment of Diagnostic Imaging, University Children's Hospital, Zürich, Switzerland.
Annette HackenbergDepartment of Pediatric Neurology, University Children's Hospital, Zürich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuromyelitis optica spectrum disorder (NMOSD) is a rare neuroinflammatory disease with an annual incidence of less than 1 case in 1,000,000 in the White population and a median age of onset at 40 years. NMOSD usually presents with optic neuritis and longitudinally extensive transverse myelitis. Various brainstem, cerebellar, diencephalic, and hemispheric symptoms may also occur. Early diagnosis and treatment are crucial for symptom management and prevention of relapses and disability. We report the case of a prepubertal girl, highlighting unique clinical and magnetic resonance imaging features and the risk of early parenchymal damage.

Indexed as

Aquaporin 4Disorders of Excessive SomnolenceNeuromyelitis OpticaAutoantibodiesChildFemaleHumansMagnetic Resonance ImagingAQP4 protein, humanAquaporin 4Autoantibodies

Identifiers

PMID40456289
PMCPMC12419872

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.