ReviewJornal brasileiro de nefrologia
Skin microcirculation and hypertension: is there a connection?
Review in Jornal brasileiro de nefrologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Assessing the Health and Functionality of the Microcirculation Using Thermal Imaging.Journal of biophotonics · 2026Review
- Microvascular Health as a Key Determinant of Organismal Aging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHypertension is an important risk factor for myocardial infarction, stroke, peripheral arterial disease, and chronic kidney disease. The World Health Organization has determined that approximately 1.28 billion adults worldwide have high blood pressure. Its definition has changed over the years, and in 2017 the American College of Cardiology and the American Heart Association have defined blood pressures ≥ 130/80 mmHg as hypertension.
methodsThe PubMed database was searched using the MeSH terms sodium, capillary resistance, hypertension, and microvascular rarefaction to identify articles relevant to skin sodium levels, peripheral circulations and vascular rare fraction, and hypertension.
resultsExperimental animal and human studies indicate that there are fewer capillaries and arterioles in patients with primary hypertension, and decreased density, also known as rarefaction, increases peripheral resistance. Microvascular density can be estimated noninvasively by methods such as intravital video microscopy in cutaneous regions or in nailfolds. The mechanisms of the reduction in density have been studied and could be used as a parameter when evaluating therapeutic options for patients. The skin provides a reservoir for sodium and can help moderate fluctuations in blood pressure associated with changes in sodium intake. In addition, the skin can modulate fluid volumes in the body through transepidermal water loss.
conclusionsThis review discusses microvascular rarefaction, changes in microvasculature structure including the skin capillaries with hypertension, the association between sodium and skin physiology relevant to hypertension, transepidermal water loss, and the vascular effects associated with some antihypertensive medications that help explain their benefit in the prevention of cardiovascular events.
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Registered trials
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