ReviewThe Journal of physiology2026
Repolarization adaptation to rapid change in heart rate in human models - a review.
Review in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Cardiac regulatory mechanisms: Translating fundamental discoveries into novel therapeutics.The Journal of physiology · 2026Article
- LQT1 patients have augmented response of repolarization dispersion following atropine induced heart rate increase versus healthy controls.Physiological reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Hysteresis is a ubiquitous phenomenon and a salient feature of the adaptation of cardiac ventricular repolarization (VR) duration to changes in heart rate (HR), an expression of ultra-rapid cardiac memory. Against a background of a handful of previous studies, this review focuses on non-invasive electrophysiological assessment of the adaptation of VR duration and heterogeneity (aka dispersion) to changes in HR. Four different modalities were used: atrial pacing (incremental and step up/down), ventricular pacing (step up/down), and atropine-induced continuous HR increase in healthy subjects and patients who either had permanent pacemakers or were scheduled for ablation of supraventricular tachycardia or had long QT syndrome type 1 (LQT1). Vectorcardiography according to Frank, with orthogonal leads X, Y, and Z, was used for signal recording and beat-to-beat analysis. The RR interval (instantaneous HR) was the input. VR duration was assessed by the QT and QT
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Registered trials
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