Evidence map›Paper›PMID 40455863›Full record

ArticlePloS one2025

Effectiveness of aerobic physical exercise on depression symptoms in adults: A protocol for developing a systematic review and meta-analysis of randomized clinical trials.

Larissa Nayara de Souza, Silvana Medeiros de Araújo, Eva da Silva Paiva, Alícia Eliege da Silva, Joel Florêncio da Costa Neto, Juvêncio César Lima de Assis, Isis Kelly Dos Santos, Themis Cristina Mesquita Soares, Edson Fonseca Pinto, Roque Ribeiro da Silva Júnior and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Larissa Nayara de SouzaPrograma de Pós-Graduação em Saúde e Sociedade pela Universidade do Estado do Rio Grande do Norte, Mossoró, Brazil.ORCID 0009-0003-1928-6328
Silvana Medeiros de AraújoPrograma de Pós-Graduação em Saúde e Sociedade pela Universidade do Estado do Rio Grande do Norte, Mossoró, Brazil.
Eva da Silva PaivaPrograma de Pós-Graduação em Saúde e Sociedade pela Universidade do Estado do Rio Grande do Norte, Mossoró, Brazil.
Alícia Eliege da SilvaPrograma de Pós-Graduação em Saúde e Sociedade pela Universidade do Estado do Rio Grande do Norte, Mossoró, Brazil.
Joel Florêncio da Costa NetoPrograma de Pós-Graduação em Saúde e Sociedade pela Universidade do Estado do Rio Grande do Norte, Mossoró, Brazil.
Juvêncio César Lima de AssisPrograma de Pós-Graduação em Saúde e Sociedade pela Universidade do Estado do Rio Grande do Norte, Mossoró, Brazil.
Isis Kelly Dos SantosPrograma de Pós-Graduação em Saúde e Sociedade pela Universidade do Estado do Rio Grande do Norte, Mossoró, Brazil.
Themis Cristina Mesquita SoaresPrograma de Mestrado Acadêmico em Planejamento e Dinâmicas Territoriais no Semiárido PLANDITES-CAPF-UERN, Pau dos Ferros, Brazil.
Edson Fonseca PintoPrograma de Pós-Graduação em Saúde Coletiva PPGScol pela Universidade Federal do Rio Grande do Norte, Natal, Brazil.
Roque Ribeiro da Silva JúniorPrograma Multicêntrico de Pós-graduação em Ciências Fisiológicas pela Universidade do Estado do Rio Grande Norte, Mossoro, Brazil.
Maria Irany KnackfussPrograma de Pós-Graduação em Saúde e Sociedade pela Universidade do Estado do Rio Grande do Norte, Mossoró, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDepression is a chronic condition that affects millions of people and requires effective interventions. Studies suggest that aerobic exercise can improve mental health and reduce depression symptoms, despite variations in exercise type and intensity.

objectiveThis article presents a protocol for conducting a systematic review with meta-analysis, aimed at investigating the effects of aerobic exercise on reducing depression symptoms in adults.

methodsThis is a systematic review protocol, which will follow the PRISMA-P 2020 guidelines and has been registered in PROSPERO (no. CRD42024592700). The study search will be conducted in six databases: BVS, Cochrane library, Embase, Epistemonikos, PubMed and SPORTDiscus, using MeSH-based descriptors. Studies will be selected independently by two researchers using the Rayyan 'QCRI' software. Data extraction will be performed using specific forms, while the methodological quality of studies on physical exercise will be assessed with the TESTEX tool, and the risk of bias will be evaluated using the Cochrane RoB 2.0 method. The certainty of evidence will be evaluated through the Grading of Recommendations Assessment, Development, and Evaluation (GRADE).

conclusionsIt is expected that the systematic review following this protocol will identify the effective dose-response to reduce depression levels and provide an understanding of the mechanisms through which aerobic exercise influences depression.

Indexed as

DepressionExerciseExercise TherapyAdultHumansMeta-Analysis as TopicRandomized Controlled Trials as TopicResearch DesignSystematic Reviews as Topic

Identifiers

PMID40455863
PMCPMC12129328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.