Evidence map›Paper›PMID 40455840›Full record

ArticleCirculation2025

TET2-Mutant Clonal Hematopoiesis Promotes Heart Failure With Preserved Ejection Fraction.

Ambarish Pandey, Toby Thomas, Yuanyuan Ji, Benjamin Kroger, Peter Carlsgaard, Camila I Irion, Fatma Kalkan, Matthew Segar, Vinayak Subramanian, Antoni Bayés-Genís and 10 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Ambarish Pandey *Division of Cardiology, Department of Internal Medicine (A.P., C.I.I., M.S., V.S., N.J., D.D., S.A.W., D.T.), UT Southwestern Medical Center, Dallas, TX.ORCID 0000-0001-9651-3836
Toby Thomas *Division of Hematology/Oncology, Department of Internal Medicine (T.T., Y.J., B.K., P.C., F.K., A.S., N.P., S.S.C.), UT Southwestern Medical Center, Dallas, TX.ORCID 0009-0004-1707-4951
Yuanyuan Ji *Division of Hematology/Oncology, Department of Internal Medicine (T.T., Y.J., B.K., P.C., F.K., A.S., N.P., S.S.C.), UT Southwestern Medical Center, Dallas, TX.ORCID 0000-0001-8324-1376
Benjamin KrogerDivision of Hematology/Oncology, Department of Internal Medicine (T.T., Y.J., B.K., P.C., F.K., A.S., N.P., S.S.C.), UT Southwestern Medical Center, Dallas, TX.ORCID 0000-0001-5675-9102
Peter CarlsgaardDivision of Hematology/Oncology, Department of Internal Medicine (T.T., Y.J., B.K., P.C., F.K., A.S., N.P., S.S.C.), UT Southwestern Medical Center, Dallas, TX.ORCID 0000-0003-3053-7645
Camila I IrionDivision of Cardiology, Department of Internal Medicine (A.P., C.I.I., M.S., V.S., N.J., D.D., S.A.W., D.T.), UT Southwestern Medical Center, Dallas, TX.ORCID 0000-0001-8143-043X
Fatma KalkanDivision of Hematology/Oncology, Department of Internal Medicine (T.T., Y.J., B.K., P.C., F.K., A.S., N.P., S.S.C.), UT Southwestern Medical Center, Dallas, TX.ORCID 0000-0002-1053-1193
Matthew SegarDivision of Cardiology, Department of Internal Medicine (A.P., C.I.I., M.S., V.S., N.J., D.D., S.A.W., D.T.), UT Southwestern Medical Center, Dallas, TX.ORCID 0000-0001-6100-0897
Vinayak SubramanianDivision of Cardiology, Department of Internal Medicine (A.P., C.I.I., M.S., V.S., N.J., D.D., S.A.W., D.T.), UT Southwestern Medical Center, Dallas, TX.
Antoni Bayés-GenísAutonomous University of Barcelona, Spain (A.B.G.).ORCID 0000-0002-3044-197X
Albert SonDivision of Hematology/Oncology, Department of Internal Medicine (T.T., Y.J., B.K., P.C., F.K., A.S., N.P., S.S.C.), UT Southwestern Medical Center, Dallas, TX.ORCID 0000-0001-5185-9075
Kira A YoungThe Jackson Laboratory, Bar Harbor, ME (K.A.Y., J.J.T.).
Jennifer J TrowbridgeThe Jackson Laboratory, Bar Harbor, ME (K.A.Y., J.J.T.).
Naveen PremnathDivision of Hematology/Oncology, Department of Internal Medicine (T.T., Y.J., B.K., P.C., F.K., A.S., N.P., S.S.C.), UT Southwestern Medical Center, Dallas, TX.ORCID 0000-0001-5183-2657
Nan JiangDivision of Cardiology, Department of Internal Medicine (A.P., C.I.I., M.S., V.S., N.J., D.D., S.A.W., D.T.), UT Southwestern Medical Center, Dallas, TX.
Daniel DaouDivision of Cardiology, Department of Internal Medicine (A.P., C.I.I., M.S., V.S., N.J., D.D., S.A.W., D.T.), UT Southwestern Medical Center, Dallas, TX.ORCID 0000-0002-9912-6855
Wenhuo HuDepartment of Pathology, Center of Excellence for Leukemia Studies, St. Jude Children's Research Hospital, Memphis, TN (W.H.).ORCID 0000-0002-8686-7160
Sarah A WareDivision of Cardiology, Department of Internal Medicine (A.P., C.I.I., M.S., V.S., N.J., D.D., S.A.W., D.T.), UT Southwestern Medical Center, Dallas, TX.ORCID 0000-0002-2387-1613
Dan Tong *Division of Cardiology, Department of Internal Medicine (A.P., C.I.I., M.S., V.S., N.J., D.D., S.A.W., D.T.), UT Southwestern Medical Center, Dallas, TX.ORCID 0000-0002-3551-2861
Stephen S Chung *Division of Hematology/Oncology, Department of Internal Medicine (T.T., Y.J., B.K., P.C., F.K., A.S., N.P., S.S.C.), UT Southwestern Medical Center, Dallas, TX.ORCID 0000-0002-1433-7419

Funding

Developing Effective Approaches to Extend Hematopoietic Healthspan by Targeting Cell-Extrinsic and Cell-Intrinsic Alterations at Middle AgeR01DK118072 · NIDDK · JACKSON LABORATORY · PI Jennifer Jean Trowbridge · 2018 to 2026
$4.2M
Inflammatory Signaling in DNMT3A-Mutated Human Hematopoietic Stem CellsU01AG077925 · NIA · JACKSON LABORATORY · PI LEVINE, ROSS L, TROWBRIDGE, JENNIFER JEAN · 2021 to 2025
$2.9M
Polypill strategy for the evidence-based management of heart failure with reduced ejection fraction in an underserved patient populationR01MD017529 · NIMHD · UT SOUTHWESTERN MEDICAL CENTER · PI PANDEY, AMBARISH, WANG, THOMAS J. · 2022 to 2025
$2.9M
Discovery of Aging-Associated Mechanisms Causing Expansion and Progression of Clonal Hematopoiesis of Indeterminant Potential (CHIP)R01AG069010 · NIA · JACKSON LABORATORY · PI TROWBRIDGE, JENNIFER JEAN · 2020 to 2024
$2.4M
Regulation of Protein Synthesis in Leukemia Stem CellsR37CA273232 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Stephen Shiu-Wah Chung · 2023 to 2026
$1.9M
Characterization of CD99 as a Therapeutic Target in the Myelodysplastic Syndromes and Acute Myeloid LeukemiaK08CA194275 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI CHUNG, STEPHEN SHIU-WAH · 2017 to 2021
$843k
Protein acetylation-dependent fatty acid metabolic dysfunction in HFpEFK08HL157697 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Dan Tong · 2022 to 2026
$738k
Cardiac biomarkers, intensive blood pressure treatment and risk of adverse cardiovascular outcomes in type 2 diabetes, a secondary analysis of the ACCORD BPR21HL169708 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI PANDEY, AMBARISH · 2023 to 2024
$261k
Understanding Transplant Relapse of the Myelodysplastic Syndromes through Early Detection of Residual Disease among Hematopoietic Stem CellsF30HL178281 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Benjamin Kroger · 2025 to 2026
$88k
NCI NIH HHS K08 CA194275NCI NIH HHS R37 CA273232NHLBI NIH HHS F30 HL178281NHLBI NIH HHS K08 HL157697NHLBI NIH HHS R21 HL169708NIA NIH HHS R01 AG069010NIA NIH HHS U01 AG077925NIDDK NIH HHS R01 DK118072NIMHD NIH HHS R01 MD017529
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40455840
PMCPMC12805981

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.