SynthesisPloS one2025
The effects of low-load resistance training combined with blood flow restriction on knee rehabilitation in middle-aged and elderly patients: A systematic review and meta-analysis.
Synthesis in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Early-Phase Quadriceps Activation After Knee Surgery: A Narrative Review of Current Rehabilitation Interventions and Identification of an Unmet Clinical Need.Journal of clinical medicine · 2026Review
- A hierarchical integration model of effort perception: peripheral, central, cognitive, temporal, and applied mechanisms revealed through blood flow restriction.Frontiers in neuroergonomics · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This meta-analysis evaluates the effectiveness of low-load resistance training combined with blood flow restriction in knee rehabilitation.
methodsRandomized controlled trials investigating the effects of blood flow restriction training on knee injury rehabilitation were systematically searched in the PubMed, EBSCO, and Web of Science databases for studies published between January 2000 and May 2024. The Cochrane Risk of Bias Tool was used to assess study quality, and statistical analyses were performed using Review Manager 5.3 software.
results(1) Compared to low-load control training, blood flow restriction training showed no significant difference in pain scores (standardized mean difference = -0.10, P = 0.46) but significantly improved muscle strength (standardized mean difference = 1.11, P < 0.00001). (2) When compared to high-intensity resistance training, blood flow restriction training demonstrated no significant differences in muscle strength (standardized mean difference = -0.11, P = 0.74) or pain scores (standardized mean difference = -0.84, P = 0.17). (3) Preoperative blood flow restriction training did not significantly improve postoperative pain scores (standardized mean difference = 0.77, P = 0.37); however, among 241 patients undergoing preoperative training, blood flow restriction training significantly enhanced postoperative muscle strength (standardized mean difference = 0.97, P = 0.03).
conclusionsAlthough blood flow restriction training has limited effects on reducing pain, it significantly improves muscle strength, particularly in preoperative rehabilitation and low-load training settings, making it a valuable alternative in clinical knee rehabilitation strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.