ArticlePLoS neglected tropical diseases2025
Soluble triggering receptor expressed on myeloid cells 1 is associated with hemoconcentration and endothelial activation in children and young adults with dengue virus infection in the Philippines.
Article in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mechanistic constraints in dengue severity: a systematic review with evidence stratification and agent-based evaluation of logical sufficiency.Frontiers in immunology · 2026Pooled it
- Beyond Hemostasis: Platelet Biomarkers and Vascular-Immune Crosstalk in Dengue.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Validation of China's 2025 high-risk criteria in RT-PCR-confirmed chikungunya inpatients: a single-centre retrospective cohort.BMC infectious diseases · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundTriggering receptor expressed on myeloid cells 1 (TREM1) is a cell-surface receptor expressed on neutrophils that amplifies the inflammatory response. Dengue virus (DENV) infection is characterized by systemic inflammation, endothelial activation, and vascular leakage. METHODOLOGY/PRINCIPAL
findingsWe investigated circulating soluble TREM-1 (sTREM-1) levels in 244 children and young adults aged 1-26 years with dengue fever presenting to an outpatient clinic in the Philippines. Elevated sTREM-1 (≥130 pg/mL) was associated with hemoconcentration, a hallmark of vascular leakage (odds ratio (OR) 3.8, 95%CI 1.6-10, p = 0.0020). In turn, hemoconcentration was associated with hospitalization (OR 4.2, 95%CI 1.0-38, p = 0.0497) and higher volume of intravenous fluid required for resuscitation (p = 0.019). Elevated inflammation marker TNF (≥5 pg/mL) was associated with increased sTREM-1 levels (p = 0.0014). Endothelial activation markers angiopoietin-2 (Ang-2), soluble FMS-like tyrosine kinase-1 (sFlt-1), and soluble vascular cell adhesion molecule 1 (sVCAM-1) were correlated with sTREM-1 levels (p < 0.0001 for all three comparisons). CONCLUSIONS/SIGNIFICANCE: Our findings suggest that sTREM-1 may be a clinically informative marker of neutrophil activation, associated with hemoconcentration, systemic inflammation, and endothelial activation and in dengue fever.
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